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• W1994651976 abstract "Plasminogen activator inhibitor type-1 (PAI-1) inhibits tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which convert plasminogen to plasmin, a strong proteolytic enzyme. Thus, PAI-1 is a primary and negative regulator of plasmin-driven proteolysis. In addition to its main role as an inhibitor of fibrinolysis, PAI‑1 has been implicated as a mediator in other processes, including fibrosis, rheumatoid arthritis, atherosclerosis, tumor angiogenesis and bacterial infections. It also significantly modulates cellular adhesion or migration, wound healing, angiogenesis and tumor cell metastasis. However, in the present study, we have reviewed the literature in relation to different kidney diseases where PAI-1 regulates fibrinolysis and acts independently of proteolysis. PAI-1 is normally produced in trace amounts in healthy kidneys but is synthesized in a wide variety of both acute and chronic diseased kidneys. We reviewed the role of PAI-1 in diabetic kidney nephropathy, chronic kidney disease, hemodialysis, peritoneal dialysis and in kidney transplantation. Increased PAI-1 expression results in accumulation of extracellular matrix (ECM) leading to numerous kidney diseases. Predisposition to some diseases is due to the genetic role of PAI-1 in their development. A number of studies demonstrated that the inhibition of PAI-1 activity or therapy with a mutant PAI-1 increases matrix turnover and reduces glomerulosclerosis by competing with endogenous PAI-1. This strongly suggests that PAI-1 is a valid target in the treatment of fibrotic renal disease. However, net proteolytic activity depends on the delicate balance between its negative regulation by PAI-1 and activation by uPA and tPA. Also, plasmin activated by its inhibitors upregulates activity of other enzymes. Thus, assessment of prognosis for the diseased kidney should include a variety of proteolysis regulators and enzymes." @default.
• W1994651976 created "2016-06-24" @default.
• W1994651976 creator A5026381921 @default.
• W1994651976 creator A5079636370 @default.
• W1994651976 creator A5082254113 @default.
• W1994651976 date "2013-01-10" @default.
• W1994651976 modified "2023-09-30" @default.
• W1994651976 title "Plasminogen activator inhibitor-1 in kidney pathology" @default.
• W1994651976 cites W1963596900 @default.
• W1994651976 cites W1972117538 @default.
• W1994651976 cites W1973771885 @default.
• W1994651976 cites W1973796961 @default.
• W1994651976 cites W1975158646 @default.
• W1994651976 cites W1979013314 @default.
• W1994651976 cites W1981341408 @default.
• W1994651976 cites W1985844444 @default.
• W1994651976 cites W1989132922 @default.
• W1994651976 cites W1992255677 @default.
• W1994651976 cites W1993416374 @default.
• W1994651976 cites W1995316596 @default.
• W1994651976 cites W1998286178 @default.
• W1994651976 cites W1998669923 @default.
• W1994651976 cites W2000640783 @default.
• W1994651976 cites W2004969894 @default.
• W1994651976 cites W2007499677 @default.
• W1994651976 cites W2008579409 @default.
• W1994651976 cites W2009606495 @default.
• W1994651976 cites W2011501529 @default.
• W1994651976 cites W2011516611 @default.
• W1994651976 cites W2012194625 @default.
• W1994651976 cites W2012719951 @default.
• W1994651976 cites W2019203967 @default.
• W1994651976 cites W201947058 @default.
• W1994651976 cites W2023216924 @default.
• W1994651976 cites W2027615770 @default.
• W1994651976 cites W2028615837 @default.
• W1994651976 cites W2032444690 @default.
• W1994651976 cites W2036417358 @default.
• W1994651976 cites W2038178085 @default.
• W1994651976 cites W2040732264 @default.
• W1994651976 cites W2040808476 @default.
• W1994651976 cites W2048502689 @default.
• W1994651976 cites W2050886787 @default.
• W1994651976 cites W2051480219 @default.
• W1994651976 cites W2052142949 @default.
• W1994651976 cites W2056257151 @default.
• W1994651976 cites W2057989908 @default.
• W1994651976 cites W2061530032 @default.
• W1994651976 cites W2062208260 @default.
• W1994651976 cites W2062969878 @default.
• W1994651976 cites W2066538838 @default.
• W1994651976 cites W2068993479 @default.
• W1994651976 cites W2069686392 @default.
• W1994651976 cites W2071770551 @default.
• W1994651976 cites W2080014204 @default.
• W1994651976 cites W2084040603 @default.
• W1994651976 cites W2093699014 @default.
• W1994651976 cites W2097937744 @default.
• W1994651976 cites W2101692513 @default.
• W1994651976 cites W2112532118 @default.
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• W1994651976 cites W2121730673 @default.
• W1994651976 cites W2124424546 @default.
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• W1994651976 cites W2126644103 @default.
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• W1994651976 cites W2133413135 @default.
• W1994651976 cites W2134059227 @default.
• W1994651976 cites W2136094514 @default.
• W1994651976 cites W2140603717 @default.
• W1994651976 cites W2148081733 @default.
• W1994651976 cites W2156195451 @default.
• W1994651976 cites W2156835645 @default.
• W1994651976 cites W2157304932 @default.
• W1994651976 cites W2161002492 @default.
• W1994651976 cites W2162579163 @default.
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• W1994651976 cites W32427409 @default.
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• W1994651976 cites W4300695220 @default.
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• W1994651976 doi "https://doi.org/10.3892/ijmm.2013.1234" @default.
• W1994651976 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23314920" @default.
• W1994651976 hasPublicationYear "2013" @default.
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