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• W1994663145 abstract "The aim of the study was to evaluate the effect of rosuvastatin and atorvastatin on endothelial dysfunction, lipid peroxidation, tissue cholesterol and plasma lipids in dyslipidemic rabbits. Forty male New Zealand white rabbits were divided into four groups (n = 10): mixed dyslipidemia (GH), normal cholesterol (GN), rosuvastatin (GHR) and atorvastatin (GHA). The animals were fed a cholesterol diet supplemented with 0.5% fat and 10% coconut oil for 45 days. On the 15th day, blood samples were collected by puncture of the marginal ear vein for a total plasma cholesterol determination before starting treatment and distribution of animals in groups with similar blood cholesterol levels. Diet plus rosuvastatin and atorvastatin was administered by gavage in daily doses of 2.5 mg and 10 mg respectively. At the end of the experiment, after 45 days, the blood sample was collected by cardiac puncture was measured for cholesterol, HDL-C, LDL-C, TG and isolation of LDL. The animals were sacrificed by dislocation of cervical spine, and the aorta was removed for the study of endothelial function, measurement of tissue cholesterol, LDL and MDA. The results were compared by nonparametric statistical methods. There was a significant increase in all parameters studied in GH compared to GN. There was a significant reduction in all parameters when comparing GHR and GHA to GH. As for effectiveness in reducing CT, TG, LDL-C and LDLox, GHA was shown to be more efficient than the GHR. However, for tissue cholesterol, MDA and endothelial dysfunction, there were no statistically differences between both groups. Rosuvastatin and atorvastatin were similar in improving endothelial dysfunction, reduction in tissue cholesterol and lipid peroxidation. Detectar el efecto de rosuvastatina y atorvastatina en disfunción endotelial, peroxidación lipídica, colesterol y lípidos en tejidos en conejos dislipémicos. Conejos machos, asignados al azar: dislipemia mixta (GH), no hipercolesterolémicos (GN), rosuvastatina (GHR) y atorvastatina (GHA) (n = 10). Con dieta suplementada con grasa de coco al 10% y colesterol al 0,5% w/w por 45 días; 15 días después, con punción venosa en la vena marginal de la oreja se recogieron muestras de sangre para determinar el colesterol total plasmático con la finalidad de iniciar el tratamiento y distribuir a los animales en los grupos con grados semejantes de colesterolemia. Se administró dieta + rosuvastatina 2,5 mg y atorvastatina 10 mg por día por animal de GHR y GHA. Después de 45 días se recolectaron muestras de sangre por punción cardíaca para determinación de colesterol, triglicéridos (TG), colesterol de las lipoproteínas de alta densidad (cHDL) y colesterol de las lipoproteínas de baja densidad (cLDL). Los conejos fueron sacrificados por desplazamiento de la columna cervical. Mediante toracotomía se retiró la aorta para estudio de función endotelial, medida del colesterol en tejidos, malondialdehído (MDA) de pared de aorta y cLDL. Los resultados se compararon por métodos estadísticos no paramétricos. Se demostró el aumento de los parámetros estudiados en GH en relación con GN. En GHR y GHA hubo reducción significativa de parámetros en relación con GH. Hubo diferencia significativa en resultados entre GHA, que fue más eficiente en la disminución de CT, TG y cLDL, en relación con GHR. Sin embargo, en relación con el colesterol en tejido, MDA y disfunción endotelial no hubo diferencias significativas entre GHR y GHA. Los resultados demostraron que rosuvastatina y atorvastatina son eficientes en la mejora de la disfunción endotelial, al reducir la susceptibilidad del cLDL para sufrir peroxidación y el colesterol en los tejidos." @default.
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• W1994663145 date "2009-11-01" @default.
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• W1994663145 title "Endothelium function, lipid peroxidation, plasmatic and tissue cholesterol evaluations in mixed dyslipidemia in rabbits treated with rosuvastatin and atorvastatin" @default.
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