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- W1994670519 abstract "The objective of this study was to examine the association between body mass index (BMI) and the annual estimated glomerular filtration rate (eGFR) decline in a rural lean Chinese cohort. A total of 2696 subjects with an eGFR ⩾60 ml/min per 1.73 m2 were followed up for 7 years. Our primary outcome was annual eGFR decline, calculated as (eGFR at baseline−eGFR at revisit)/years of follow-up. During the 7-year follow-up, the mean (s.d.) of annual eGFR decline was 1.7 (1.9) ml/min per 1.73 m2 per year. Compared with subjects with normal weight (BMI 19–22.9 kg/m2), overweight subjects (BMI 23–26.9 kg/m2) had a more rapid annual eGFR decline (β, 0.33; 95% confidence interval (0.18–0.47) ml/min per 1.73 m2 per year), whereas no significant difference was found when comparing the underweight (<19 kg/m2) and the obese (⩾27 kg/m2) groups with the normal-weight group. Moreover, in the 19- to 26.9-kg/m2 range, BMI was positively linearly associated with annual eGFR decline (β2, 0.09 (0.05 to 0.12) ml/min per 1.73 m2 per year, P<0.001), whereas in the <19 (β1, −0.21(−0.45–0.02), P=0.073; β2 versus β1: P=0.009) and ⩾27 kg/m2 (β3, −0.24 (−0.48–0.00), P=0.053; β3 versus β2: P=0.010) range a negative but statistically insignificant trend of association was detected. Our results suggested a nonlinear S-shaped association between BMI and annual eGFR decline among Chinese adults with normal renal function." @default.
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- W1994670519 date "2014-10-29" @default.
- W1994670519 modified "2023-09-23" @default.
- W1994670519 title "Body mass index and annual estimated GFR decline in Chinese adults with normal renal function" @default.
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- W1994670519 doi "https://doi.org/10.1038/ejcn.2014.221" @default.
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