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- W1994680370 endingPage "68" @default.
- W1994680370 startingPage "53" @default.
- W1994680370 abstract "Cells have to cope with stressful conditions and adapt to changing environments. Heat stress, heavy metal ions or UV stress induce damage to cellular proteins and disturb the balanced status of the proteome. The adjusted balance between folded and folding proteins, called protein homoeostasis, is required for every aspect of cellular functionality. Protective proteins called chaperones are expressed under extreme conditions in order to prevent aggregation of cellular proteins and safeguard protein quality. These chaperones co-operate during de novo folding, refolding and disaggregation of damaged proteins and in many cases refold them to their functional state. Even under physiological conditions these machines support protein homoeostasis and maintain the balance between de novo folding and degradation. Mutations generating unstable proteins, which are observed in numerous human diseases such as Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis and cystic fibrosis, also challenge the protein quality control system. A better knowledge of how the protein homoeostasis system is regulated will lead to an improved understanding of these diseases and provide potential targets for therapy." @default.
- W1994680370 created "2016-06-24" @default.
- W1994680370 creator A5043675140 @default.
- W1994680370 creator A5073229910 @default.
- W1994680370 date "2014-08-18" @default.
- W1994680370 modified "2023-09-23" @default.
- W1994680370 title "Protein folding, misfolding and quality control: the role of molecular chaperones" @default.
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