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- W1994687610 abstract "Shikimic acid (SA) is the drug lead of oseltamivir phosphate (Tamiflu®). The pharmaceutical industry has great demand for SA to match the production of the drug. This article describes the development of an integrated expanded-bed adsorption chromatography (EBAC) system and its application in SA extraction and separation. The hydrodynamic behavior of an expanded-bed ion exchange resin, D293, was investigated to show that D293 resin is able to act as an adsorbent for recovery of SA from Illicium verum. SA was extracted from 8 g of I. verum in 150 mL of deionized water at an expansion ratio of 1.4 via integrated EBAC at 40°C. The SA was then eluted in 200 mL of a 2% NaCl solution. The recovery rate of SA was 96.7% and its purity was 59.6%. Different methods were compared, and the results indicated that the method developed in this article is promising for the recovery of SA from I. verum. The process efficiency of the integrated method was 2.6 times higher than that of the conventional method, while its energy efficiency was about 6 times of that of the conventional method." @default.
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- W1994687610 date "2014-04-03" @default.
- W1994687610 modified "2023-09-23" @default.
- W1994687610 title "Integrated Expanded-Bed Ion Exchange Chromatography as a Tool for Direct Recovery of Shikimic Acid from<i>Illicium verum</i>" @default.
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- W1994687610 doi "https://doi.org/10.1080/07366299.2014.899870" @default.
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