FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994689667> ?p ?o ?g. }

• W1994689667 endingPage "788" @default.
• W1994689667 startingPage "782" @default.
• W1994689667 abstract "Glucocorticoids are the key regulators of the biological stress response and act by binding to glucocorticoid receptors (GR). Expression of GR is altered by DNA methylation. Methylation patterns in GR promoters have been shown to be highly variable between individuals, but little is known about the functional consequences of this variation for the acute stress response. The present study investigated associations between methylation status of the GR 1-C promoter and cortisol, cardiovascular and perceived stress responses to a psychosocial stress protocol in a large healthy adult population. A total of 725 overall healthy men and women, aged 55–60 years, participated in a standardized psychosocial stress protocol consisting of three different stressors. At different stages during the stress protocol, salivary cortisol levels, continuous blood pressure and heart rate (HR) levels as well as perceived stress were measured. Stress reactivity was calculated as the increase between basal and peak measurements. Methylation status of the GR 1-C promoter was assessed in DNA isolated from peripheral blood samples using a methylation sensitive PCR assay for 675 of the 725 participants. A decrease in methylation of the GR 1-C promoter was associated with a decrease in stress reactivity as indicated by lower cortisol and lower HR reactivity. A 1% decrease in GR 1-C methylation corresponded with a cortisol decrease by 0.14% (95% CI: 0.03–0.25, p = 0.02) and an HR decrease by 0.10 bpm (0.03–0.16, p = 0.003). Adjusting for sex, lifestyle and education largely abolished these associations. A decrease in methylation of the GR 1-C promoter was also associated with an increase in stress perception as indicated by higher perceived stress (0.03 points [0.00–0.06, p = 0.05]), lower perceived performance (−0.03 points [−0.05 to −0.01], p = 0.02), and lower perceived control (−0.03 points [−0.05 to 0.00], p = 0.04). After adjusting for sex and educational level the associations were no longer statistically significant. GR 1-C methylation status was not associated with blood pressure responses to the stress protocol. Although effects were small, variation in methylation status in the GR 1-C promoter was associated with physical and perceived acute stress responses. Interestingly, these associations could largely be explained by differences in lifestyle and education." @default.
• W1994689667 created "2016-06-24" @default.
• W1994689667 creator A5007654742 @default.
• W1994689667 creator A5020342789 @default.
• W1994689667 creator A5024619720 @default.
• W1994689667 creator A5030546346 @default.
• W1994689667 creator A5046808655 @default.
• W1994689667 creator A5058979039 @default.
• W1994689667 creator A5076773270 @default.
• W1994689667 creator A5084544884 @default.
• W1994689667 date "2012-06-01" @default.
• W1994689667 modified "2023-10-10" @default.
• W1994689667 title "Associations between DNA methylation of a glucocorticoid receptor promoter and acute stress responses in a large healthy adult population are largely explained by lifestyle and educational differences" @default.
• W1994689667 cites W1967632125 @default.
• W1994689667 cites W1968787277 @default.
• W1994689667 cites W1984171442 @default.
• W1994689667 cites W2001711719 @default.
• W1994689667 cites W2002758528 @default.
• W1994689667 cites W2010289173 @default.
• W1994689667 cites W2036905475 @default.
• W1994689667 cites W2054692302 @default.
• W1994689667 cites W2069288651 @default.
• W1994689667 cites W2091413411 @default.
• W1994689667 cites W2100773564 @default.
• W1994689667 cites W2106670153 @default.
• W1994689667 cites W2118812285 @default.
• W1994689667 cites W2125625276 @default.
• W1994689667 cites W2134111903 @default.
• W1994689667 cites W2137542514 @default.
• W1994689667 cites W2161577136 @default.
• W1994689667 cites W2166194564 @default.
• W1994689667 cites W2169090691 @default.
• W1994689667 cites W2170760271 @default.
• W1994689667 cites W2171712162 @default.
• W1994689667 doi "https://doi.org/10.1016/j.psyneuen.2011.09.010" @default.
• W1994689667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21978868" @default.
• W1994689667 hasPublicationYear "2012" @default.
• W1994689667 type Work @default.
• W1994689667 sameAs 1994689667 @default.
• W1994689667 citedByCount "46" @default.
• W1994689667 countsByYear W19946896672012 @default.
• W1994689667 countsByYear W19946896672013 @default.
• W1994689667 countsByYear W19946896672014 @default.
• W1994689667 countsByYear W19946896672015 @default.
• W1994689667 countsByYear W19946896672016 @default.
• W1994689667 countsByYear W19946896672017 @default.
• W1994689667 countsByYear W19946896672018 @default.
• W1994689667 countsByYear W19946896672019 @default.
• W1994689667 countsByYear W19946896672020 @default.
• W1994689667 countsByYear W19946896672021 @default.
• W1994689667 countsByYear W19946896672022 @default.
• W1994689667 countsByYear W19946896672023 @default.
• W1994689667 crossrefType "journal-article" @default.
• W1994689667 hasAuthorship W1994689667A5007654742 @default.
• W1994689667 hasAuthorship W1994689667A5020342789 @default.
• W1994689667 hasAuthorship W1994689667A5024619720 @default.
• W1994689667 hasAuthorship W1994689667A5030546346 @default.
• W1994689667 hasAuthorship W1994689667A5046808655 @default.
• W1994689667 hasAuthorship W1994689667A5058979039 @default.
• W1994689667 hasAuthorship W1994689667A5076773270 @default.
• W1994689667 hasAuthorship W1994689667A5084544884 @default.
• W1994689667 hasBestOaLocation W19946896671 @default.
• W1994689667 hasConcept C101762097 @default.
• W1994689667 hasConcept C104317684 @default.
• W1994689667 hasConcept C118552586 @default.
• W1994689667 hasConcept C125370674 @default.
• W1994689667 hasConcept C126322002 @default.
• W1994689667 hasConcept C134018914 @default.
• W1994689667 hasConcept C150194340 @default.
• W1994689667 hasConcept C150966472 @default.
• W1994689667 hasConcept C15744967 @default.
• W1994689667 hasConcept C190727270 @default.
• W1994689667 hasConcept C2780841215 @default.
• W1994689667 hasConcept C2908647359 @default.
• W1994689667 hasConcept C33288867 @default.
• W1994689667 hasConcept C54355233 @default.
• W1994689667 hasConcept C552990157 @default.
• W1994689667 hasConcept C59493245 @default.
• W1994689667 hasConcept C70410870 @default.
• W1994689667 hasConcept C71924100 @default.
• W1994689667 hasConcept C86803240 @default.
• W1994689667 hasConcept C99454951 @default.
• W1994689667 hasConceptScore W1994689667C101762097 @default.
• W1994689667 hasConceptScore W1994689667C104317684 @default.
• W1994689667 hasConceptScore W1994689667C118552586 @default.
• W1994689667 hasConceptScore W1994689667C125370674 @default.
• W1994689667 hasConceptScore W1994689667C126322002 @default.
• W1994689667 hasConceptScore W1994689667C134018914 @default.
• W1994689667 hasConceptScore W1994689667C150194340 @default.
• W1994689667 hasConceptScore W1994689667C150966472 @default.
• W1994689667 hasConceptScore W1994689667C15744967 @default.
• W1994689667 hasConceptScore W1994689667C190727270 @default.
• W1994689667 hasConceptScore W1994689667C2780841215 @default.
• W1994689667 hasConceptScore W1994689667C2908647359 @default.
• W1994689667 hasConceptScore W1994689667C33288867 @default.
• W1994689667 hasConceptScore W1994689667C54355233 @default.
• W1994689667 hasConceptScore W1994689667C552990157 @default.
• W1994689667 hasConceptScore W1994689667C59493245 @default.

• next