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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994690625> ?p ?o ?g. }

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• W1994690625 abstract "The human sodium-dependent vitamin C transporters (hSVCT1 and hSVCT2) mediate cellular uptake of ascorbic acid. Both these transporters contain potential sites for N-glycosylation in their extracellular domains (Asn-138, Asn-144 [hSVCT1]; Asn-188, Asn-196 [hSVCT2]), however the role of N-glycosylation in transporter function is unexplored. On the basis of the result that tunicamycin decreased 14C-ascorbic acid uptake in HepG2 cells, we systematically ablated all consensus N-glycosylation sites in hSVCT1 and hSVCT2 to resolve any effects on ascorbic acid uptake, transporter expression and targeting. We show that removal of individual N-glycosylation sites significantly impairs protein expression and consequently ascorbic acid uptake for hSVCT1 mutants (N138Q is retained intracellularly) and for hSVCT2 mutants (all of which reach the cell surface). N-Glycosylation is therefore essential for vitamin C transporter functionality." @default.
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• W1994690625 date "2008-09-01" @default.
• W1994690625 modified "2023-09-24" @default.
• W1994690625 title "N-Glycosylation is required for Na+-dependent vitamin C transporter functionality" @default.
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• W1994690625 doi "https://doi.org/10.1016/j.bbrc.2008.06.120" @default.
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