FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994704865> ?p ?o ?g. }

• W1994704865 endingPage "128" @default.
• W1994704865 startingPage "117" @default.
• W1994704865 abstract "This study aimed to assess the role of constitutive protein kinase CK2 in cytokine-induced activation of NFκB in pancreatic β cell death. The CK2 inhibitors DRB (5,6-dichloro-1-β-D-ribofuranosylbenzimidazole) (50 μM) and DMAT (2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole) (5 μM), which decreased CK2 activity by approx. 65 %, rescued INS-1E β cells and mouse islets from cytokine (IL-1β, TNF-α plus IFN-γ)-induced β cell death without affecting H2O2- or palmitate-induced β cell death. Western blot analysis revealed that while DRB or DMAT did not influence cytokine-induced IκBα degradation, they inhibited NFκB-dependent IκBα resynthesis, demonstrating that cytokine-induced NFκB activity is dependent on CK2. Both DRB and DMAT inhibited the constitutive phosphorylation of NFκB p65 at serine 529, while leaving cytokine-induced phosphorylations of NFκB p65 at serines 276 and 536 unaltered. In comparison, putative phosphorylation sites for CK2 on HDACs 1, 2, and 3 at serines 421/423, 394, and 424, respectively, which may stimulate NFκB transcriptional activity, were unchanged by cytokines and CK2 inhibitors. Whereas IL-1β and TNF-α stimulate IκBα degradation and NFκB activation, IFN-γ potentiates cytokine-induced β cell death through activation of STAT1. DRB and DMAT inhibited IFN-γ-stimulated phosphorylation of STAT1 at serine 727, while leaving IFN-γ-induced phosphorylation of STAT1 at tyrosine 701 unaffected. Inhibition of cytokine-induced β cell death by CK2 inhibitors was, however, not dependent on IFN-γ, and IFN-γ did not affect CK2-dependent IκBα turnover. In conclusion, it is suggested that cytokine-induced activation of NFκB in β cells is dependent on CK2 activity, which phosphorylates NFκB p65 at serine 529." @default.
• W1994704865 created "2016-06-24" @default.
• W1994704865 creator A5005867601 @default.
• W1994704865 creator A5022024849 @default.
• W1994704865 date "2013-12-24" @default.
• W1994704865 modified "2023-10-06" @default.
• W1994704865 title "A critical role for CK2 in cytokine-induced activation of NFκB in pancreatic β cell death" @default.
• W1994704865 cites W1484201256 @default.
• W1994704865 cites W1934086060 @default.
• W1994704865 cites W1964276861 @default.
• W1994704865 cites W1968512250 @default.
• W1994704865 cites W1987855588 @default.
• W1994704865 cites W1990082535 @default.
• W1994704865 cites W1991390641 @default.
• W1994704865 cites W1994567337 @default.
• W1994704865 cites W1994755988 @default.
• W1994704865 cites W1999734356 @default.
• W1994704865 cites W2005164022 @default.
• W1994704865 cites W2009141757 @default.
• W1994704865 cites W2011024261 @default.
• W1994704865 cites W2011219963 @default.
• W1994704865 cites W2016167871 @default.
• W1994704865 cites W2019372747 @default.
• W1994704865 cites W2023565096 @default.
• W1994704865 cites W2047809719 @default.
• W1994704865 cites W2051427152 @default.
• W1994704865 cites W2052908553 @default.
• W1994704865 cites W2057861572 @default.
• W1994704865 cites W2060163314 @default.
• W1994704865 cites W2068407084 @default.
• W1994704865 cites W2082948150 @default.
• W1994704865 cites W2087527433 @default.
• W1994704865 cites W2099351017 @default.
• W1994704865 cites W2104675452 @default.
• W1994704865 cites W2114918609 @default.
• W1994704865 cites W2116482468 @default.
• W1994704865 cites W2120653342 @default.
• W1994704865 cites W2142098891 @default.
• W1994704865 cites W2144639685 @default.
• W1994704865 cites W2146561547 @default.
• W1994704865 cites W2154434798 @default.
• W1994704865 cites W2155045727 @default.
• W1994704865 cites W2157476554 @default.
• W1994704865 cites W2159963744 @default.
• W1994704865 cites W2162980664 @default.
• W1994704865 cites W2315434755 @default.
• W1994704865 cites W4252748475 @default.
• W1994704865 doi "https://doi.org/10.1007/s12020-013-0133-6" @default.
• W1994704865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4145192" @default.
• W1994704865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24366643" @default.
• W1994704865 hasPublicationYear "2013" @default.
• W1994704865 type Work @default.
• W1994704865 sameAs 1994704865 @default.
• W1994704865 citedByCount "11" @default.
• W1994704865 countsByYear W19947048652015 @default.
• W1994704865 countsByYear W19947048652016 @default.
• W1994704865 countsByYear W19947048652017 @default.
• W1994704865 countsByYear W19947048652018 @default.
• W1994704865 countsByYear W19947048652019 @default.
• W1994704865 countsByYear W19947048652021 @default.
• W1994704865 countsByYear W19947048652022 @default.
• W1994704865 crossrefType "journal-article" @default.
• W1994704865 hasAuthorship W1994704865A5005867601 @default.
• W1994704865 hasAuthorship W1994704865A5022024849 @default.
• W1994704865 hasBestOaLocation W19947048651 @default.
• W1994704865 hasConcept C11960822 @default.
• W1994704865 hasConcept C134018914 @default.
• W1994704865 hasConcept C153911025 @default.
• W1994704865 hasConcept C165220095 @default.
• W1994704865 hasConcept C185592680 @default.
• W1994704865 hasConcept C190283241 @default.
• W1994704865 hasConcept C203014093 @default.
• W1994704865 hasConcept C2777003663 @default.
• W1994704865 hasConcept C2777553839 @default.
• W1994704865 hasConcept C2777730290 @default.
• W1994704865 hasConcept C2778690821 @default.
• W1994704865 hasConcept C2779306644 @default.
• W1994704865 hasConcept C2779730028 @default.
• W1994704865 hasConcept C2779855799 @default.
• W1994704865 hasConcept C31573885 @default.
• W1994704865 hasConcept C55493867 @default.
• W1994704865 hasConcept C62478195 @default.
• W1994704865 hasConcept C86803240 @default.
• W1994704865 hasConcept C95444343 @default.
• W1994704865 hasConceptScore W1994704865C11960822 @default.
• W1994704865 hasConceptScore W1994704865C134018914 @default.
• W1994704865 hasConceptScore W1994704865C153911025 @default.
• W1994704865 hasConceptScore W1994704865C165220095 @default.
• W1994704865 hasConceptScore W1994704865C185592680 @default.
• W1994704865 hasConceptScore W1994704865C190283241 @default.
• W1994704865 hasConceptScore W1994704865C203014093 @default.
• W1994704865 hasConceptScore W1994704865C2777003663 @default.
• W1994704865 hasConceptScore W1994704865C2777553839 @default.
• W1994704865 hasConceptScore W1994704865C2777730290 @default.
• W1994704865 hasConceptScore W1994704865C2778690821 @default.
• W1994704865 hasConceptScore W1994704865C2779306644 @default.
• W1994704865 hasConceptScore W1994704865C2779730028 @default.
• W1994704865 hasConceptScore W1994704865C2779855799 @default.

• next