FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994706170> ?p ?o ?g. }

• W1994706170 endingPage "781" @default.
• W1994706170 startingPage "769" @default.
• W1994706170 abstract "A series of iodonicotinamides based on the melanin-binding iodobenzamide compound N-2-diethylaminoethyl-4-iodobenzamide was prepared and evaluated for the potential imaging and staging of disseminated metastatic melanoma.[(123)I]Iodonicotinamides were prepared by iododestannylation reactions using no-carrier-added iodine-123 and evaluated in vivo by biodistribution and competition studies and by single photon emission computed tomography (SPECT) imaging in black and albino nude mice bearing B16F0 murine melanotic and A375 human amelanotic melanoma tumours, respectively.The iodonicotinamides displayed low-affinity binding for sigma(1)-sigma(2) receptors (K(i)>300 nM). In biodistribution studies in mice, N-(2-(diethylamino)ethyl)-5-[(123)I]iodonicotinamide ([(123)I]1) exhibited the fastest and highest uptake of the nicotinamide series in the B16F0 tumour at 1 h ( approximately 8% ID/g), decreasing slowly over time. No uptake was observed in the A375 tumour. Clearance from the animals by urinary excretion was more rapid for N-alkyl-nicotinamides than for piperazinyl derivatives. At 1 h postinjection, the urinary excretion was 66% ID for [(123)I]1, while the gastrointestinal tract amounted to 17% ID. Haloperidol was unable to reduce the uptake of [(123)I]1 in pigmented mice, indicating that this uptake was likely due to an interaction with melanin. SPECT imaging of [(123)I]1 in black mice bearing the B16F0 melanoma indicated that the radioactivity was predominately located in the tumour and eyes. No specific localisation was observed in nude mice bearing A375 amelanotic tumours.These findings suggest that [(123)I]1, which displays high tumour uptake with rapid clearance from the body, could be a promising imaging agent for the detection of melanotic tumours." @default.
• W1994706170 created "2016-06-24" @default.
• W1994706170 creator A5002535442 @default.
• W1994706170 creator A5013096089 @default.
• W1994706170 creator A5015034206 @default.
• W1994706170 creator A5053518334 @default.
• W1994706170 creator A5056448190 @default.
• W1994706170 creator A5059361174 @default.
• W1994706170 creator A5061857934 @default.
• W1994706170 creator A5072373299 @default.
• W1994706170 creator A5074844643 @default.
• W1994706170 date "2008-10-01" @default.
• W1994706170 modified "2023-10-17" @default.
• W1994706170 title "Synthesis and evaluation of novel radioiodinated nicotinamides for malignant melanoma" @default.
• W1994706170 cites W1521200025 @default.
• W1994706170 cites W1965548174 @default.
• W1994706170 cites W1983457410 @default.
• W1994706170 cites W1997962056 @default.
• W1994706170 cites W2018202197 @default.
• W1994706170 cites W2021184272 @default.
• W1994706170 cites W2022967150 @default.
• W1994706170 cites W2029520555 @default.
• W1994706170 cites W2034587939 @default.
• W1994706170 cites W2042599884 @default.
• W1994706170 cites W2048709650 @default.
• W1994706170 cites W2050563394 @default.
• W1994706170 cites W2053426528 @default.
• W1994706170 cites W2058918559 @default.
• W1994706170 cites W2072720625 @default.
• W1994706170 cites W2072740092 @default.
• W1994706170 cites W2074125979 @default.
• W1994706170 cites W2078121025 @default.
• W1994706170 cites W2089729203 @default.
• W1994706170 cites W2089769584 @default.
• W1994706170 cites W2090813436 @default.
• W1994706170 cites W2145995820 @default.
• W1994706170 cites W2334444895 @default.
• W1994706170 cites W4233890855 @default.
• W1994706170 cites W4239651351 @default.
• W1994706170 doi "https://doi.org/10.1016/j.nucmedbio.2008.05.011" @default.
• W1994706170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18848662" @default.
• W1994706170 hasPublicationYear "2008" @default.
• W1994706170 type Work @default.
• W1994706170 sameAs 1994706170 @default.
• W1994706170 citedByCount "18" @default.
• W1994706170 countsByYear W19947061702013 @default.
• W1994706170 countsByYear W19947061702015 @default.
• W1994706170 countsByYear W19947061702016 @default.
• W1994706170 countsByYear W19947061702017 @default.
• W1994706170 countsByYear W19947061702018 @default.
• W1994706170 countsByYear W19947061702020 @default.
• W1994706170 countsByYear W19947061702021 @default.
• W1994706170 countsByYear W19947061702022 @default.
• W1994706170 countsByYear W19947061702023 @default.
• W1994706170 crossrefType "journal-article" @default.
• W1994706170 hasAuthorship W1994706170A5002535442 @default.
• W1994706170 hasAuthorship W1994706170A5013096089 @default.
• W1994706170 hasAuthorship W1994706170A5015034206 @default.
• W1994706170 hasAuthorship W1994706170A5053518334 @default.
• W1994706170 hasAuthorship W1994706170A5056448190 @default.
• W1994706170 hasAuthorship W1994706170A5059361174 @default.
• W1994706170 hasAuthorship W1994706170A5061857934 @default.
• W1994706170 hasAuthorship W1994706170A5072373299 @default.
• W1994706170 hasAuthorship W1994706170A5074844643 @default.
• W1994706170 hasConcept C107538193 @default.
• W1994706170 hasConcept C142724271 @default.
• W1994706170 hasConcept C150903083 @default.
• W1994706170 hasConcept C185592680 @default.
• W1994706170 hasConcept C202751555 @default.
• W1994706170 hasConcept C207001950 @default.
• W1994706170 hasConcept C2777658100 @default.
• W1994706170 hasConcept C2777807558 @default.
• W1994706170 hasConcept C2778172261 @default.
• W1994706170 hasConcept C2779190346 @default.
• W1994706170 hasConcept C2984398910 @default.
• W1994706170 hasConcept C2989005 @default.
• W1994706170 hasConcept C502942594 @default.
• W1994706170 hasConcept C55493867 @default.
• W1994706170 hasConcept C71924100 @default.
• W1994706170 hasConcept C86803240 @default.
• W1994706170 hasConceptScore W1994706170C107538193 @default.
• W1994706170 hasConceptScore W1994706170C142724271 @default.
• W1994706170 hasConceptScore W1994706170C150903083 @default.
• W1994706170 hasConceptScore W1994706170C185592680 @default.
• W1994706170 hasConceptScore W1994706170C202751555 @default.
• W1994706170 hasConceptScore W1994706170C207001950 @default.
• W1994706170 hasConceptScore W1994706170C2777658100 @default.
• W1994706170 hasConceptScore W1994706170C2777807558 @default.
• W1994706170 hasConceptScore W1994706170C2778172261 @default.
• W1994706170 hasConceptScore W1994706170C2779190346 @default.
• W1994706170 hasConceptScore W1994706170C2984398910 @default.
• W1994706170 hasConceptScore W1994706170C2989005 @default.
• W1994706170 hasConceptScore W1994706170C502942594 @default.
• W1994706170 hasConceptScore W1994706170C55493867 @default.
• W1994706170 hasConceptScore W1994706170C71924100 @default.
• W1994706170 hasConceptScore W1994706170C86803240 @default.
• W1994706170 hasIssue "7" @default.
• W1994706170 hasLocation W19947061701 @default.

• next