FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994706197> ?p ?o ?g. }

• W1994706197 abstract "Circulating inhibin alpha concentrations were determined in infant, juvenile, and adult male rhesus monkeys with a RIA employing antisera to a synthetic fragment of the alpha-subunit of porcine inhibin. Binding of tracer, [DSer1,Nle5]human inhibin alpha(1-25)-Gly-125I-Tyr, to antibody was inhibited by standard, [DSer1,Nle5]human inhibin alpha(1-25)-Gly-Tyr. and by plasma from adult male monkeys in a parallel fashion. Castration in adults resulted in a 5-fold decline in the levels of immunoreactivity in plasma. Mean (+/- SE) plasma inhibin alpha concentrations in infants and adults (322.9 +/- 51.9 and 460.1 +/- 43.9 pg/ml, respectively) were significantly higher (P less than 0.05) than those in juveniles (191.3 +/- 28.3 pg/ml). Moreover, initiation of puberty in juvenile males, 13-18 months of age, with a chronic (10- to 12-week) intermittent iv infusion of GnRH (0.1 microgram/min for 3 min every 3 h) resulted in a progressive rise in circulating inhibin alpha that plateaued, after 5 weeks of pituitary stimulation, at concentrations (343.9 +/- 38.2 pg/ml) comparable to those of infants and adults and twice those observed before initiation of the pulsatile infusion of GnRH. Circulating FSH concentrations increased during the first week of GnRH stimulation from 2.7 +/- 0.1 ng/ml before treatment to 6.0 +/- 1.2 ng/ml, where they remained for the duration of the experiment. Testosterone secretion during the initiation of precocious puberty occurred in discrete episodes that were robustly correlated with GnRH-induced LH discharges. In contrast, changes in circulating inhibin alpha concentrations over the 3-h interval between GnRH pulses were unremarkable. Activation of Sertoli and Leydig cells during initiation of puberty in the juvenile males, as reflected by circulating inhibin alpha and testosterone concentrations, respectively, occurred with similar time courses. At the time of orchidectomy, 10-12 weeks after initiation of GnRH treatment, testicular tissue was prepared for histological examination. In spite of a 2-fold gain in testicular weight and in hypertrophy of Sertoli cells in association with GnRH stimulation, maturation of the germinal epithelium did not progress past prophase I spermatocytes, and the number of these latter cells was meager. These findings indicate that the testis of the infant primate, like that of the adult, secretes significant amounts of inhibin, and that the quiescent Sertoli cell of the juvenile males may be readily provoked by appropriate gonadotropin stimulation into producing inhibin. The results also fail to provide evidence for the view that changes in circulating inhibin concentrations are robustly related, in an inve" @default.
• W1994706197 created "2016-06-24" @default.
• W1994706197 creator A5013808498 @default.
• W1994706197 creator A5037046079 @default.
• W1994706197 creator A5058968656 @default.
• W1994706197 creator A5085356820 @default.
• W1994706197 date "1989-07-01" @default.
• W1994706197 modified "2023-09-27" @default.
• W1994706197 title "Circulating Inhibin α Concentrations in Infant, Prepubertal, and Adult Male Rhesus Monkeys (Macaca mulatta) and in Juvenile Males during Premature Initiation of Puberty with Pulsatile Gonadotropin-Releasing Hormone Treatment*" @default.
• W1994706197 doi "https://doi.org/10.1210/endo-125-1-250" @default.
• W1994706197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2500325" @default.
• W1994706197 hasPublicationYear "1989" @default.
• W1994706197 type Work @default.
• W1994706197 sameAs 1994706197 @default.
• W1994706197 citedByCount "29" @default.
• W1994706197 countsByYear W19947061972016 @default.
• W1994706197 countsByYear W19947061972019 @default.
• W1994706197 crossrefType "journal-article" @default.
• W1994706197 hasAuthorship W1994706197A5013808498 @default.
• W1994706197 hasAuthorship W1994706197A5037046079 @default.
• W1994706197 hasAuthorship W1994706197A5058968656 @default.
• W1994706197 hasAuthorship W1994706197A5085356820 @default.
• W1994706197 hasConcept C115961737 @default.
• W1994706197 hasConcept C126322002 @default.
• W1994706197 hasConcept C134018914 @default.
• W1994706197 hasConcept C24998067 @default.
• W1994706197 hasConcept C2778575703 @default.
• W1994706197 hasConcept C2778782382 @default.
• W1994706197 hasConcept C2778894405 @default.
• W1994706197 hasConcept C2779256933 @default.
• W1994706197 hasConcept C2779279991 @default.
• W1994706197 hasConcept C54355233 @default.
• W1994706197 hasConcept C71315377 @default.
• W1994706197 hasConcept C71924100 @default.
• W1994706197 hasConcept C79191276 @default.
• W1994706197 hasConcept C86803240 @default.
• W1994706197 hasConceptScore W1994706197C115961737 @default.
• W1994706197 hasConceptScore W1994706197C126322002 @default.
• W1994706197 hasConceptScore W1994706197C134018914 @default.
• W1994706197 hasConceptScore W1994706197C24998067 @default.
• W1994706197 hasConceptScore W1994706197C2778575703 @default.
• W1994706197 hasConceptScore W1994706197C2778782382 @default.
• W1994706197 hasConceptScore W1994706197C2778894405 @default.
• W1994706197 hasConceptScore W1994706197C2779256933 @default.
• W1994706197 hasConceptScore W1994706197C2779279991 @default.
• W1994706197 hasConceptScore W1994706197C54355233 @default.
• W1994706197 hasConceptScore W1994706197C71315377 @default.
• W1994706197 hasConceptScore W1994706197C71924100 @default.
• W1994706197 hasConceptScore W1994706197C79191276 @default.
• W1994706197 hasConceptScore W1994706197C86803240 @default.
• W1994706197 hasLocation W19947061971 @default.
• W1994706197 hasLocation W19947061972 @default.
• W1994706197 hasOpenAccess W1994706197 @default.
• W1994706197 hasPrimaryLocation W19947061971 @default.
• W1994706197 hasRelatedWork W2004275026 @default.
• W1994706197 hasRelatedWork W2012502375 @default.
• W1994706197 hasRelatedWork W2014200423 @default.
• W1994706197 hasRelatedWork W2020563687 @default.
• W1994706197 hasRelatedWork W2021091460 @default.
• W1994706197 hasRelatedWork W2039222105 @default.
• W1994706197 hasRelatedWork W2068877544 @default.
• W1994706197 hasRelatedWork W2078661233 @default.
• W1994706197 hasRelatedWork W2108619254 @default.
• W1994706197 hasRelatedWork W2153400994 @default.
• W1994706197 isParatext "false" @default.
• W1994706197 isRetracted "false" @default.
• W1994706197 magId "1994706197" @default.
• W1994706197 workType "article" @default.