FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994717156> ?p ?o ?g. }

• W1994717156 endingPage "340" @default.
• W1994717156 startingPage "335" @default.
• W1994717156 abstract "Several in vitro studies suggest that gonadotropin-secreting pituitary adenomas (Gn-omas) and non functioning pituitary adenomas (NFPA) originate from gonadotroph cells. Patients with Gn-oma and NFPA frequently show abnormal gonadotropin response to TRH. The aim of the study was to investigate whether the estrogen-induced negative feedback is operating in either patients with Gn-oma or NFPA.Serum gonadotropin levels were evaluated at 24 h after ethinylestradiol administration (1 mg per os; EE2 test) in seven patients with a diagnosis of Gn-oma, based on the presence of high follicle-stimulating hormone (FSH) and/or lutenising hormone (LH) levels with normal or high levels of sex steroids, in 22 patients with NFPA with normal or low levels of gonadotropin and sex steroids, and 30 sex- and age-matched healthy subjects. A normal response to EE2 test was arbitrarily defined as a serum LH and FSH decrease of at least 40 and 30% below basal levels.Among patients with Gn-oma, only one had a normal FSH inhibition and another, a normal LH inhibition. Among the 22 patients with NFPA, the EE2 test caused a normal FSH or LH reduction in 10 and 15, respectively, while a normal reduction of both FSH and LH was observed in nine.The study demonstrates that estrogen-induced negative feedback of gonadotropin secretion is disrupted in almost all patients with Gn-oma and in half of those with NFPA. This defective feedback is reminiscent of the resistance to thyroid hormones and glucocorticoids observed in patients with thyroid-stimulating hormone- (TSH-) and adrenocorticotropic hormone- (ACTH-)secreting adenomas, respectively." @default.
• W1994717156 created "2016-06-24" @default.
• W1994717156 creator A5010644767 @default.
• W1994717156 creator A5011245991 @default.
• W1994717156 creator A5023054623 @default.
• W1994717156 creator A5037404198 @default.
• W1994717156 creator A5041064460 @default.
• W1994717156 creator A5042420012 @default.
• W1994717156 creator A5078350860 @default.
• W1994717156 creator A5081095524 @default.
• W1994717156 creator A5083801591 @default.
• W1994717156 creator A5087923558 @default.
• W1994717156 date "2002-05-01" @default.
• W1994717156 modified "2023-10-18" @default.
• W1994717156 title "Impaired estrogen-induced negative feedback on gonadotropin secretion in patients with gonadotropin-secreting and nonfunctioning pituitary adenomas" @default.
• W1994717156 cites W1973859002 @default.
• W1994717156 cites W1977504110 @default.
• W1994717156 cites W1985239266 @default.
• W1994717156 cites W2002526474 @default.
• W1994717156 cites W2024881534 @default.
• W1994717156 cites W2046216532 @default.
• W1994717156 cites W2054267961 @default.
• W1994717156 cites W2092094647 @default.
• W1994717156 cites W2092219783 @default.
• W1994717156 cites W2106680731 @default.
• W1994717156 cites W2112924740 @default.
• W1994717156 cites W2118020663 @default.
• W1994717156 cites W2128242453 @default.
• W1994717156 cites W2321613759 @default.
• W1994717156 cites W4230655335 @default.
• W1994717156 cites W4234912535 @default.
• W1994717156 cites W4239225010 @default.
• W1994717156 cites W4241538055 @default.
• W1994717156 cites W4241683314 @default.
• W1994717156 cites W4243252855 @default.
• W1994717156 cites W4246646475 @default.
• W1994717156 cites W4247544040 @default.
• W1994717156 cites W4250111403 @default.
• W1994717156 doi "https://doi.org/10.1046/j.1365-2362.2002.00981.x" @default.
• W1994717156 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12027873" @default.
• W1994717156 hasPublicationYear "2002" @default.
• W1994717156 type Work @default.
• W1994717156 sameAs 1994717156 @default.
• W1994717156 citedByCount "8" @default.
• W1994717156 countsByYear W19947171562012 @default.
• W1994717156 countsByYear W19947171562014 @default.
• W1994717156 countsByYear W19947171562020 @default.
• W1994717156 countsByYear W19947171562021 @default.
• W1994717156 crossrefType "journal-article" @default.
• W1994717156 hasAuthorship W1994717156A5010644767 @default.
• W1994717156 hasAuthorship W1994717156A5011245991 @default.
• W1994717156 hasAuthorship W1994717156A5023054623 @default.
• W1994717156 hasAuthorship W1994717156A5037404198 @default.
• W1994717156 hasAuthorship W1994717156A5041064460 @default.
• W1994717156 hasAuthorship W1994717156A5042420012 @default.
• W1994717156 hasAuthorship W1994717156A5078350860 @default.
• W1994717156 hasAuthorship W1994717156A5081095524 @default.
• W1994717156 hasAuthorship W1994717156A5083801591 @default.
• W1994717156 hasAuthorship W1994717156A5087923558 @default.
• W1994717156 hasConcept C126322002 @default.
• W1994717156 hasConcept C134018914 @default.
• W1994717156 hasConcept C2777164284 @default.
• W1994717156 hasConcept C2778024521 @default.
• W1994717156 hasConcept C2778575703 @default.
• W1994717156 hasConcept C2778782382 @default.
• W1994717156 hasConcept C2779279165 @default.
• W1994717156 hasConcept C2779306644 @default.
• W1994717156 hasConcept C71315377 @default.
• W1994717156 hasConcept C71924100 @default.
• W1994717156 hasConcept C86803240 @default.
• W1994717156 hasConceptScore W1994717156C126322002 @default.
• W1994717156 hasConceptScore W1994717156C134018914 @default.
• W1994717156 hasConceptScore W1994717156C2777164284 @default.
• W1994717156 hasConceptScore W1994717156C2778024521 @default.
• W1994717156 hasConceptScore W1994717156C2778575703 @default.
• W1994717156 hasConceptScore W1994717156C2778782382 @default.
• W1994717156 hasConceptScore W1994717156C2779279165 @default.
• W1994717156 hasConceptScore W1994717156C2779306644 @default.
• W1994717156 hasConceptScore W1994717156C71315377 @default.
• W1994717156 hasConceptScore W1994717156C71924100 @default.
• W1994717156 hasConceptScore W1994717156C86803240 @default.
• W1994717156 hasIssue "5" @default.
• W1994717156 hasLocation W19947171561 @default.
• W1994717156 hasLocation W19947171562 @default.
• W1994717156 hasOpenAccess W1994717156 @default.
• W1994717156 hasPrimaryLocation W19947171561 @default.
• W1994717156 hasRelatedWork W2000170411 @default.
• W1994717156 hasRelatedWork W2024649280 @default.
• W1994717156 hasRelatedWork W2063235021 @default.
• W1994717156 hasRelatedWork W2067304466 @default.
• W1994717156 hasRelatedWork W2122018218 @default.
• W1994717156 hasRelatedWork W2145229803 @default.
• W1994717156 hasRelatedWork W2163840050 @default.
• W1994717156 hasRelatedWork W2468044930 @default.
• W1994717156 hasRelatedWork W2006611219 @default.
• W1994717156 hasRelatedWork W2294497689 @default.
• W1994717156 hasVolume "32" @default.
• W1994717156 isParatext "false" @default.

• next