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• W1994730306 abstract "Studies are described regarding generation of anti-hapten antibodies starting with a monoclonal Ig immunogen in the ligand-induced conformation or metalypic state. Liganded monoclonal Ab1 antibodies represent the unique feature of the study since previous reports investigating internal imaging in the original Idiotype Network Hypothesis [Jerne, 1974 (Ann. Immun. 125C, 373–389)] were based on the non-liganded or idiotypic state [as reviewed in: Rodkey, 1980 (Microbiol. Rev. 44, 631–659); Kohler et al., 1979 (In: Methods in Enzymology: Antibodies, Antigens and Molecular Mimicry, pp. 3–35); Greenspan and Bona, 1993 (FASEB J. 7, 437–444)]. Affinity-labeled liganded murine monoclonal anti-fluorescein antibodies served as immunogens administered both in the syngenic and xenogenic modes to determine if the metatypic state elicited anti-hapten antibodies through imaging-like mechanisms. Polyclonal and monoclonal anti-Ab1 reagents in various hosts were assayed for anti-fluorescein and/or anti-metatype specificity. Significant anti-fluorescein responses were measured indicating that the metatypic state directly or indirectly stimulates an anti-hapten antibody population." @default.
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• W1994730306 date "1996-05-01" @default.
• W1994730306 modified "2023-10-18" @default.
• W1994730306 title "Antibody networks and imaging: Elicatation of anti-fluorescein antibodies in response to the metatypic state of fluorescein-specific monoclonal antibodies" @default.
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• W1994730306 doi "https://doi.org/10.1016/0161-5890(96)00003-x" @default.
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