Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994733451> ?p ?o ?g. }
- W1994733451 endingPage "60" @default.
- W1994733451 startingPage "54" @default.
- W1994733451 abstract "Synthetic suppressive oligodeoxynucleotides (ODNs) expressing TTAGGG motifs selectively reduce Th1 cytokine production and have been proven effective in T helper type 1 (Th1)-mediated autoimmune diseases. Concanavalin A (Con A)-induced hepatitis is characterized by elevated Th1 response. The present study aims to reveal a profound hepatoprotective effect of suppressive ODNs on Con A-induced hepatitis. BALB/c mice were injected with suppressive ODNs (i) prior to, (ii) simultaneously with, or (iii) after Con A challenge. The effect of suppressive ODNs on interferon (IFN)-γ and interleukin (IL)-4 expressions was determined. The effect of suppressive ODNs on signal modulators for Th1/Th2 pathway was examined. Our results showed that suppressive ODNs significantly reduced liver necroinflammatory injury and serum IFN-γ level, meanwhile increased IL-4 level. The mortality of suppressive ODNs-treated mice was reduced from 30% to 0% in 8 h post Con A challenge. In the splenic lymphocytes, Western blot analysis showed that suppressive ODNs down-regulated the phosphorylation of signal transducer and activator of transcription 1 (STAT1) and STAT4, and suppressed up-regulation of T-bet, but did not impact the phosphorylation of STAT6 which are associated with a Th2 phenotype. Consistent with this in vivo observation, ELISA analysis demonstrated that suppressive ODNs inhibited IFN-γ, and augmented IL-4 production in the differentiation of naive T cells in vitro. We concluded that suppressive ODNs inhibit the development of Con A-induced hepatitis through down-regulation of the STAT1/4 and T-bet pathways and may be of use in the treatment of autoimmune or viral hepatitis in humans." @default.
- W1994733451 created "2016-06-24" @default.
- W1994733451 creator A5031810848 @default.
- W1994733451 creator A5036571865 @default.
- W1994733451 creator A5051886373 @default.
- W1994733451 creator A5059386453 @default.
- W1994733451 creator A5059947196 @default.
- W1994733451 creator A5074610068 @default.
- W1994733451 creator A5074832030 @default.
- W1994733451 date "2013-03-01" @default.
- W1994733451 modified "2023-09-27" @default.
- W1994733451 title "Protective role of synthetic oligodeoxynucleotides expressing immunosuppressive TTAGGG motifs in concanavalin A-induced hepatitis" @default.
- W1994733451 cites W1542158894 @default.
- W1994733451 cites W1580932873 @default.
- W1994733451 cites W1586179339 @default.
- W1994733451 cites W1639777098 @default.
- W1994733451 cites W1856085327 @default.
- W1994733451 cites W1922754836 @default.
- W1994733451 cites W1968213123 @default.
- W1994733451 cites W1976273464 @default.
- W1994733451 cites W1982178416 @default.
- W1994733451 cites W1988147176 @default.
- W1994733451 cites W1990478798 @default.
- W1994733451 cites W1996249257 @default.
- W1994733451 cites W2003747312 @default.
- W1994733451 cites W2019215354 @default.
- W1994733451 cites W2022782373 @default.
- W1994733451 cites W2028161109 @default.
- W1994733451 cites W2043204829 @default.
- W1994733451 cites W2043803403 @default.
- W1994733451 cites W2045457857 @default.
- W1994733451 cites W2047110135 @default.
- W1994733451 cites W2049483717 @default.
- W1994733451 cites W2061517203 @default.
- W1994733451 cites W2091647757 @default.
- W1994733451 cites W2094673598 @default.
- W1994733451 cites W2096496776 @default.
- W1994733451 cites W2099014795 @default.
- W1994733451 cites W2109403608 @default.
- W1994733451 cites W2128840852 @default.
- W1994733451 cites W2143309964 @default.
- W1994733451 cites W2144218024 @default.
- W1994733451 cites W2145360982 @default.
- W1994733451 cites W2165617398 @default.
- W1994733451 cites W2166835417 @default.
- W1994733451 cites W4238652665 @default.
- W1994733451 cites W4313343471 @default.
- W1994733451 doi "https://doi.org/10.1016/j.imlet.2013.02.004" @default.
- W1994733451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23470496" @default.
- W1994733451 hasPublicationYear "2013" @default.
- W1994733451 type Work @default.
- W1994733451 sameAs 1994733451 @default.
- W1994733451 citedByCount "5" @default.
- W1994733451 countsByYear W19947334512014 @default.
- W1994733451 countsByYear W19947334512015 @default.
- W1994733451 countsByYear W19947334512018 @default.
- W1994733451 crossrefType "journal-article" @default.
- W1994733451 hasAuthorship W1994733451A5031810848 @default.
- W1994733451 hasAuthorship W1994733451A5036571865 @default.
- W1994733451 hasAuthorship W1994733451A5051886373 @default.
- W1994733451 hasAuthorship W1994733451A5059386453 @default.
- W1994733451 hasAuthorship W1994733451A5059947196 @default.
- W1994733451 hasAuthorship W1994733451A5074610068 @default.
- W1994733451 hasAuthorship W1994733451A5074832030 @default.
- W1994733451 hasConcept C104317684 @default.
- W1994733451 hasConcept C11960822 @default.
- W1994733451 hasConcept C145430368 @default.
- W1994733451 hasConcept C153911025 @default.
- W1994733451 hasConcept C171958077 @default.
- W1994733451 hasConcept C191732599 @default.
- W1994733451 hasConcept C19869320 @default.
- W1994733451 hasConcept C202751555 @default.
- W1994733451 hasConcept C203014093 @default.
- W1994733451 hasConcept C2776178377 @default.
- W1994733451 hasConcept C2776415932 @default.
- W1994733451 hasConcept C2777003663 @default.
- W1994733451 hasConcept C2778690821 @default.
- W1994733451 hasConcept C2778923194 @default.
- W1994733451 hasConcept C55493867 @default.
- W1994733451 hasConcept C86803240 @default.
- W1994733451 hasConcept C95444343 @default.
- W1994733451 hasConceptScore W1994733451C104317684 @default.
- W1994733451 hasConceptScore W1994733451C11960822 @default.
- W1994733451 hasConceptScore W1994733451C145430368 @default.
- W1994733451 hasConceptScore W1994733451C153911025 @default.
- W1994733451 hasConceptScore W1994733451C171958077 @default.
- W1994733451 hasConceptScore W1994733451C191732599 @default.
- W1994733451 hasConceptScore W1994733451C19869320 @default.
- W1994733451 hasConceptScore W1994733451C202751555 @default.
- W1994733451 hasConceptScore W1994733451C203014093 @default.
- W1994733451 hasConceptScore W1994733451C2776178377 @default.
- W1994733451 hasConceptScore W1994733451C2776415932 @default.
- W1994733451 hasConceptScore W1994733451C2777003663 @default.
- W1994733451 hasConceptScore W1994733451C2778690821 @default.
- W1994733451 hasConceptScore W1994733451C2778923194 @default.
- W1994733451 hasConceptScore W1994733451C55493867 @default.
- W1994733451 hasConceptScore W1994733451C86803240 @default.
- W1994733451 hasConceptScore W1994733451C95444343 @default.