Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994733893> ?p ?o ?g. }
- W1994733893 endingPage "570" @default.
- W1994733893 startingPage "561" @default.
- W1994733893 abstract "Antihypertensive medications are the most efficient drugs in achieving regression of myocardial hypertrophy in both clinical studies and animal models of hypertension. Nevertheless, there is a lack of clear and concise comparative study of their effects on the modulation of cardiomyocyte morphology and function. Here, we assessed the tissue-protective actions of 2 of these drugs, the calcium channel blocker lacidipine (3 mg/kg/day) and the angiotensin-converting enzyme-inhibitor enalapril (10 mg/kg/day) in vivo, after 8 weeks of treatment of 12-week-old spontaneously hypertensive rats, as well as in vitro, after short-term (4 min) application to isolated cardiomyocytes. Left ventricular hypertrophy (LVH) was compared at organ, tissue, and single-cell level. Our data showed that both drugs prevented the LVH of 20-week-old spontaneously hypertensive rats, but only lacidipine significantly decreased the cardiomyocyte size. Similarly, the single-cell contractility was significantly lowered in lacidipine-treated rats only. The effect of lacidipine was initiated shortly after exposure to the drug in a dose-dependent manner at 0.5 Hz, as well as at 2 Hz, with EC50 of 10−7 mol/L. These results can help in understanding the effects of these drugs on the prevention of LVH." @default.
- W1994733893 created "2016-06-24" @default.
- W1994733893 creator A5006408490 @default.
- W1994733893 creator A5006640251 @default.
- W1994733893 creator A5050937701 @default.
- W1994733893 creator A5054059185 @default.
- W1994733893 creator A5070687511 @default.
- W1994733893 creator A5088532684 @default.
- W1994733893 date "2006-04-01" @default.
- W1994733893 modified "2023-10-16" @default.
- W1994733893 title "Comparative Study of the Effects of Lacidipine and Enalapril on the Left Ventricular Cardiomyocyte Remodeling in Spontaneously Hypertensive Rats" @default.
- W1994733893 cites W1745781907 @default.
- W1994733893 cites W1963570363 @default.
- W1994733893 cites W1967535634 @default.
- W1994733893 cites W1971033431 @default.
- W1994733893 cites W1978831466 @default.
- W1994733893 cites W1993495865 @default.
- W1994733893 cites W1995958596 @default.
- W1994733893 cites W2008204515 @default.
- W1994733893 cites W2014176692 @default.
- W1994733893 cites W2019655180 @default.
- W1994733893 cites W2031552278 @default.
- W1994733893 cites W2031596931 @default.
- W1994733893 cites W2034094870 @default.
- W1994733893 cites W2040472469 @default.
- W1994733893 cites W2041745775 @default.
- W1994733893 cites W2043659211 @default.
- W1994733893 cites W2044539683 @default.
- W1994733893 cites W2047896240 @default.
- W1994733893 cites W2051819610 @default.
- W1994733893 cites W2053816472 @default.
- W1994733893 cites W2062534551 @default.
- W1994733893 cites W2065365244 @default.
- W1994733893 cites W2067091655 @default.
- W1994733893 cites W2077969109 @default.
- W1994733893 cites W2079268037 @default.
- W1994733893 cites W2090803944 @default.
- W1994733893 cites W2095367203 @default.
- W1994733893 cites W2098291803 @default.
- W1994733893 cites W2116126119 @default.
- W1994733893 cites W2128903833 @default.
- W1994733893 cites W2133851654 @default.
- W1994733893 cites W2156626620 @default.
- W1994733893 cites W2159757106 @default.
- W1994733893 cites W2165867014 @default.
- W1994733893 cites W2171549055 @default.
- W1994733893 cites W2226437153 @default.
- W1994733893 cites W2313561479 @default.
- W1994733893 cites W2314502377 @default.
- W1994733893 cites W2326936669 @default.
- W1994733893 doi "https://doi.org/10.1097/01.fjc.0000211728.23304.ad" @default.
- W1994733893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16680070" @default.
- W1994733893 hasPublicationYear "2006" @default.
- W1994733893 type Work @default.
- W1994733893 sameAs 1994733893 @default.
- W1994733893 citedByCount "10" @default.
- W1994733893 countsByYear W19947338932012 @default.
- W1994733893 countsByYear W19947338932015 @default.
- W1994733893 countsByYear W19947338932017 @default.
- W1994733893 crossrefType "journal-article" @default.
- W1994733893 hasAuthorship W1994733893A5006408490 @default.
- W1994733893 hasAuthorship W1994733893A5006640251 @default.
- W1994733893 hasAuthorship W1994733893A5050937701 @default.
- W1994733893 hasAuthorship W1994733893A5054059185 @default.
- W1994733893 hasAuthorship W1994733893A5070687511 @default.
- W1994733893 hasAuthorship W1994733893A5088532684 @default.
- W1994733893 hasBestOaLocation W19947338931 @default.
- W1994733893 hasConcept C126322002 @default.
- W1994733893 hasConcept C134018914 @default.
- W1994733893 hasConcept C150903083 @default.
- W1994733893 hasConcept C164705383 @default.
- W1994733893 hasConcept C167414201 @default.
- W1994733893 hasConcept C170493617 @default.
- W1994733893 hasConcept C207001950 @default.
- W1994733893 hasConcept C26291073 @default.
- W1994733893 hasConcept C27016395 @default.
- W1994733893 hasConcept C2775940317 @default.
- W1994733893 hasConcept C2776002628 @default.
- W1994733893 hasConcept C2776885963 @default.
- W1994733893 hasConcept C2778086073 @default.
- W1994733893 hasConcept C2779283177 @default.
- W1994733893 hasConcept C2779572014 @default.
- W1994733893 hasConcept C2780356492 @default.
- W1994733893 hasConcept C39133596 @default.
- W1994733893 hasConcept C71924100 @default.
- W1994733893 hasConcept C84393581 @default.
- W1994733893 hasConcept C86803240 @default.
- W1994733893 hasConcept C98274493 @default.
- W1994733893 hasConceptScore W1994733893C126322002 @default.
- W1994733893 hasConceptScore W1994733893C134018914 @default.
- W1994733893 hasConceptScore W1994733893C150903083 @default.
- W1994733893 hasConceptScore W1994733893C164705383 @default.
- W1994733893 hasConceptScore W1994733893C167414201 @default.
- W1994733893 hasConceptScore W1994733893C170493617 @default.
- W1994733893 hasConceptScore W1994733893C207001950 @default.
- W1994733893 hasConceptScore W1994733893C26291073 @default.
- W1994733893 hasConceptScore W1994733893C27016395 @default.
- W1994733893 hasConceptScore W1994733893C2775940317 @default.