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- W1994734199 abstract "Publisher Summary This chapter focuses on cloning and expression in microorganisms of the genetic information coding for human plasma proteins. Genetic engineering techniques allow the construction of microbial strains carrying the genetic information for plasma proteins and engineered to produce large amounts of the appropriate substance. α 1 -antitrypsin, one of the major components of plasma proteins, is synthesized in the liver. The protein (Mw 55,000 daltons) functions essentially as an inhibitor of elastase, a component involved in the degradation of lung tissues. Emphysema is the main disease encountered in α 1 -antitrypsin deficient individuals this illness, when associated with heavy pollution such as from heavy cigarette smoking and with genetic deficiency of α 1 -antitrypsin seems to result from an imbalance between protease and antiprotease activities and appears to be alleviated by intravenous injections of partially purified α 1 -antitrypsin. Haptoglobin is a serum α 2 -glycoprotein present in human and other mammals one of its functional roles is to protect kidneys from tissue destruction by binding free haemoglobin following haemolysis." @default.
- W1994734199 created "2016-06-24" @default.
- W1994734199 creator A5081867970 @default.
- W1994734199 date "1985-09-01" @default.
- W1994734199 modified "2023-09-25" @default.
- W1994734199 title "Cloning and expression in micro-organisms of the genetic information coding for human plasma proteins" @default.
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- W1994734199 doi "https://doi.org/10.1016/0168-1656(85)90020-3" @default.
- W1994734199 hasPublicationYear "1985" @default.