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• W1994734235 abstract "1 The hypothesis that low temperature converts inotropic β-adrenoceptors to α-adrenoceptors has been tested in isolated heart preparations of the frog and rat. 2 The results do not support the adrenoceptor interconversion hypothesis. In the frog ventricle strip lowering the temperature from 24°C to 14°C did not significantly alter the inotropic potency of the sympathomimetic drugs isoprenaline, adrenaline and phenylephrine and did not reduce the potency of the β-adrenoceptor blocking drug propranolol as an isoprenaline antagonist. In the isolated left atrium of the rat lowering the temperature from 31°C and 24°C to 17–19°C did not significantly alter the inotropic potency of isoprenaline, noradrenaline and phenylephrine, did not diminish the potency of the β-adrenoceptor blocking drug propranolol and did not increase the potency of the α-adrenoceptor blocking drug phentolamine. 3 Phenylephrine acted on α- and β-adrenoceptors in rat left atrium at 31°C and 24°C, but only on β-adrenoceptors at 17–19°C." @default.
• W1994734235 created "2016-06-24" @default.
• W1994734235 creator A5023604795 @default.
• W1994734235 date "1977-10-01" @default.
• W1994734235 modified "2023-10-16" @default.
• W1994734235 title "CARDIAC ADRENOCEPTORS AT LOW TEMPERATURE AND THE ADRENOCEPTOR INTERCONVERSION HYPOTHESIS" @default.
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• W1994734235 doi "https://doi.org/10.1111/j.1476-5381.1977.tb08401.x" @default.
• W1994734235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1667505" @default.
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