Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994756307> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1994756307 endingPage "265" @default.
- W1994756307 startingPage "261" @default.
- W1994756307 abstract "Dps is a ferritin-like protein with DNA-binding properties that is capable of affording protection during oxidative stress and during times of nutritional deprivation. Here we present evidence that in exponentially growing Salmonella enterica serotype Enteritidis, Dps is vital for protection against the common killing mechanism of bactericidal antibiotics, a mechanism manifested by hydroxyl radical production via the Fenton reaction. A dps deletion mutant ('dps mutant') was hypersensitive to the bactericidal antibiotics streptomycin, nalidixic acid, norfloxacin and rifampicin compared with its parental strain. However, the observed discrepancy in survivability between the dps mutant and the parental strain following exposure to bactericidal antibiotics was fully alleviated when drug-exposed cultures were treated with an iron chelator, confirming that Fenton-mediated oxidative stress was a major factor in the reduced survival rate of the dps mutant. In addition, deletion of the DNA damage-induced repair protein RecA further intensified the killing capacity of bactericidal antibiotics in a Δdps (i.e. dps deletion) background, implying that Dps and RecA may operate in a synergistic manner to protect against the common killing mechanism of bactericidal antibiotics. The relevance of this work is demonstrated by the need for new and increasingly effective bactericidal therapies. Targeting Dps may represent a means to increase the potency of bactericidal antibiotics in S. enterica and other bacterial pathogens alike." @default.
- W1994756307 created "2016-06-24" @default.
- W1994756307 creator A5012032989 @default.
- W1994756307 creator A5064728630 @default.
- W1994756307 date "2011-03-01" @default.
- W1994756307 modified "2023-09-27" @default.
- W1994756307 title "The ferritin-like protein Dps protects Salmonella enterica serotype Enteritidis from the Fenton-mediated killing mechanism of bactericidal antibiotics" @default.
- W1994756307 cites W1523985712 @default.
- W1994756307 cites W1999206316 @default.
- W1994756307 cites W2013330518 @default.
- W1994756307 cites W2023062028 @default.
- W1994756307 cites W2031932867 @default.
- W1994756307 cites W2051772736 @default.
- W1994756307 cites W2084162463 @default.
- W1994756307 cites W2116137883 @default.
- W1994756307 cites W2117087393 @default.
- W1994756307 cites W2126702940 @default.
- W1994756307 cites W2127558534 @default.
- W1994756307 cites W2147652807 @default.
- W1994756307 cites W2793938485 @default.
- W1994756307 cites W4236330195 @default.
- W1994756307 doi "https://doi.org/10.1016/j.ijantimicag.2010.11.034" @default.
- W1994756307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21295952" @default.
- W1994756307 hasPublicationYear "2011" @default.
- W1994756307 type Work @default.
- W1994756307 sameAs 1994756307 @default.
- W1994756307 citedByCount "33" @default.
- W1994756307 countsByYear W19947563072012 @default.
- W1994756307 countsByYear W19947563072013 @default.
- W1994756307 countsByYear W19947563072014 @default.
- W1994756307 countsByYear W19947563072015 @default.
- W1994756307 countsByYear W19947563072016 @default.
- W1994756307 countsByYear W19947563072018 @default.
- W1994756307 countsByYear W19947563072019 @default.
- W1994756307 countsByYear W19947563072020 @default.
- W1994756307 countsByYear W19947563072021 @default.
- W1994756307 countsByYear W19947563072022 @default.
- W1994756307 countsByYear W19947563072023 @default.
- W1994756307 crossrefType "journal-article" @default.
- W1994756307 hasAuthorship W1994756307A5012032989 @default.
- W1994756307 hasAuthorship W1994756307A5064728630 @default.
- W1994756307 hasConcept C104317684 @default.
- W1994756307 hasConcept C143065580 @default.
- W1994756307 hasConcept C185592680 @default.
- W1994756307 hasConcept C2775876089 @default.
- W1994756307 hasConcept C2776151105 @default.
- W1994756307 hasConcept C2778512257 @default.
- W1994756307 hasConcept C2778746504 @default.
- W1994756307 hasConcept C2779607309 @default.
- W1994756307 hasConcept C2781065037 @default.
- W1994756307 hasConcept C2992956773 @default.
- W1994756307 hasConcept C501593827 @default.
- W1994756307 hasConcept C523546767 @default.
- W1994756307 hasConcept C54355233 @default.
- W1994756307 hasConcept C55493867 @default.
- W1994756307 hasConcept C86803240 @default.
- W1994756307 hasConcept C89423630 @default.
- W1994756307 hasConceptScore W1994756307C104317684 @default.
- W1994756307 hasConceptScore W1994756307C143065580 @default.
- W1994756307 hasConceptScore W1994756307C185592680 @default.
- W1994756307 hasConceptScore W1994756307C2775876089 @default.
- W1994756307 hasConceptScore W1994756307C2776151105 @default.
- W1994756307 hasConceptScore W1994756307C2778512257 @default.
- W1994756307 hasConceptScore W1994756307C2778746504 @default.
- W1994756307 hasConceptScore W1994756307C2779607309 @default.
- W1994756307 hasConceptScore W1994756307C2781065037 @default.
- W1994756307 hasConceptScore W1994756307C2992956773 @default.
- W1994756307 hasConceptScore W1994756307C501593827 @default.
- W1994756307 hasConceptScore W1994756307C523546767 @default.
- W1994756307 hasConceptScore W1994756307C54355233 @default.
- W1994756307 hasConceptScore W1994756307C55493867 @default.
- W1994756307 hasConceptScore W1994756307C86803240 @default.
- W1994756307 hasConceptScore W1994756307C89423630 @default.
- W1994756307 hasIssue "3" @default.
- W1994756307 hasLocation W19947563071 @default.
- W1994756307 hasLocation W19947563072 @default.
- W1994756307 hasOpenAccess W1994756307 @default.
- W1994756307 hasPrimaryLocation W19947563071 @default.
- W1994756307 hasRelatedWork W1966892637 @default.
- W1994756307 hasRelatedWork W1977144460 @default.
- W1994756307 hasRelatedWork W2002116770 @default.
- W1994756307 hasRelatedWork W2067994654 @default.
- W1994756307 hasRelatedWork W2164906660 @default.
- W1994756307 hasRelatedWork W2248291697 @default.
- W1994756307 hasRelatedWork W2846029322 @default.
- W1994756307 hasRelatedWork W2911973517 @default.
- W1994756307 hasRelatedWork W3110839233 @default.
- W1994756307 hasRelatedWork W3188473431 @default.
- W1994756307 hasVolume "37" @default.
- W1994756307 isParatext "false" @default.
- W1994756307 isRetracted "false" @default.
- W1994756307 magId "1994756307" @default.
- W1994756307 workType "article" @default.