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- W1994764615 abstract "Abstract Chemical investigations of the cytotoxic extract of the marine fungus Curvularia sp. (strain no. 768), isolated from the red alga Acanthophora spicifera , yielded the novel macrolide apralactone A ( 1 ), as well as the antipodes of curvularin macrolides 2 – 7 . Compound 8 , a dimeric curvularin was recognised as an artefact. The structures of 1 – 8 were elucidated by interpretation of their spectroscopic data (1D and 2D NMR, CD, MS, UV and IR). Apralactone A ( 1 ) is a 14‐membered phenyl acetic acid macrolactone, and the first such compound with a 4‐chromanone substructure. Compounds 1 , 2 , 4 , 5 and 6 were found to be cytotoxic towards human tumor cell lines with mean IC 50 values in the range of 1.25 to 30.06 μ M . (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)" @default.
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- W1994764615 date "2008-10-01" @default.
- W1994764615 modified "2023-10-14" @default.
- W1994764615 title "Apralactone A and a New Stereochemical Class of Curvularins from the Marine Fungus <i>Curvularia</i> sp." @default.
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- W1994764615 doi "https://doi.org/10.1002/ejoc.200800522" @default.
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