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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994770147> ?p ?o ?g. }

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• W1994770147 abstract "Wistar rats in our laboratory breeding colony spontaneously present petit mal-like, non-convulsive, epileptic seizures. In these rats, as in other animal petit mal models, GABAmimetics, agonists of GABA-A receptors such as 4, 5, 6, 7 tetrahydroisooxazolo (5,4-c) pyridin-3-ol (THIP), or inhibitors of GABA catabolism such as gamma-vinyl GABA (GVG) or L-cycloserine (CYC), aggravated the seizures. Diazepam not only abolished the spontaneous seizures but also completely blocked the effects of the GABAmimetics, totally suppressing seizures in rats given THIP, GVG or CYC. These findings show that the mode of action of benzodiazepines is not comparable to a non-specific potentiation of GABA transmission, and suggest that the anti-absence effects of the benzodiazepines could depend on interactions with neurotransmitter systems other than GABA." @default.
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• W1994770147 date "1985-07-01" @default.
• W1994770147 modified "2023-09-24" @default.
• W1994770147 title "Diazepam antagonizes gabamimetics in rats with spontaneous petit mal-like epilepsy" @default.
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• W1994770147 doi "https://doi.org/10.1016/0014-2999(85)90338-3" @default.
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