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• W1994775902 startingPage "e1002613" @default.
• W1994775902 abstract "The Mediator complex is an essential co-regulator of RNA polymerase II that is conserved throughout eukaryotes. Here we present the first study of Mediator in the pathogenic fungus Candida albicans. We focused on the Middle domain subunit Med31, the Head domain subunit Med20, and Srb9/Med13 from the Kinase domain. The C. albicans Mediator shares some roles with model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, such as functions in the response to certain stresses and the role of Med31 in the expression of genes regulated by the activator Ace2. The C. albicans Mediator also has additional roles in the transcription of genes associated with virulence, for example genes related to morphogenesis and gene families enriched in pathogens, such as the ALS adhesins. Consistently, Med31, Med20, and Srb9/Med13 contribute to key virulence attributes of C. albicans, filamentation, and biofilm formation; and ALS1 is a biologically relevant target of Med31 for development of biofilms. Furthermore, Med31 affects virulence of C. albicans in the worm infection model. We present evidence that the roles of Med31 and Srb9/Med13 in the expression of the genes encoding cell wall adhesins are different between S. cerevisiae and C. albicans: they are repressors of the FLO genes in S. cerevisiae and are activators of the ALS genes in C. albicans. This suggests that Mediator subunits regulate adhesion in a distinct manner between these two distantly related fungal species." @default.
• W1994775902 created "2016-06-24" @default.
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• W1994775902 date "2012-04-05" @default.
• W1994775902 modified "2023-10-17" @default.
• W1994775902 title "The Functions of Mediator in Candida albicans Support a Role in Shaping Species-Specific Gene Expression" @default.
• W1994775902 cites W1506733194 @default.
• W1994775902 cites W1601315441 @default.
• W1994775902 cites W1602738992 @default.
• W1994775902 cites W1913932992 @default.
• W1994775902 cites W1937476509 @default.
• W1994775902 cites W1973518361 @default.
• W1994775902 cites W1978627780 @default.
• W1994775902 cites W1978684735 @default.
• W1994775902 cites W1981922654 @default.
• W1994775902 cites W1981926952 @default.
• W1994775902 cites W1982161126 @default.
• W1994775902 cites W1983105728 @default.
• W1994775902 cites W1984189354 @default.
• W1994775902 cites W1984325151 @default.
• W1994775902 cites W1989736694 @default.
• W1994775902 cites W1999125301 @default.
• W1994775902 cites W2002005828 @default.
• W1994775902 cites W2002221873 @default.
• W1994775902 cites W2006754735 @default.
• W1994775902 cites W2008322226 @default.
• W1994775902 cites W2021589589 @default.
• W1994775902 cites W2025074695 @default.
• W1994775902 cites W2030313654 @default.
• W1994775902 cites W2032674459 @default.
• W1994775902 cites W2033429308 @default.
• W1994775902 cites W2034837383 @default.
• W1994775902 cites W2041611856 @default.
• W1994775902 cites W2044756723 @default.
• W1994775902 cites W2047009255 @default.
• W1994775902 cites W2047207683 @default.
• W1994775902 cites W2048186818 @default.
• W1994775902 cites W2049311981 @default.
• W1994775902 cites W2055627135 @default.
• W1994775902 cites W2058249099 @default.
• W1994775902 cites W2059628138 @default.
• W1994775902 cites W2062185406 @default.
• W1994775902 cites W2066976786 @default.
• W1994775902 cites W2067631595 @default.
• W1994775902 cites W2070140841 @default.
• W1994775902 cites W2071273015 @default.
• W1994775902 cites W2072364431 @default.
• W1994775902 cites W2073138847 @default.
• W1994775902 cites W2076982117 @default.
• W1994775902 cites W2080111666 @default.
• W1994775902 cites W2085849736 @default.
• W1994775902 cites W2087400406 @default.
• W1994775902 cites W2092361302 @default.
• W1994775902 cites W2092801223 @default.
• W1994775902 cites W2094336584 @default.
• W1994775902 cites W2094762942 @default.
• W1994775902 cites W2096181481 @default.
• W1994775902 cites W2096745402 @default.
• W1994775902 cites W2097955653 @default.
• W1994775902 cites W2099320155 @default.
• W1994775902 cites W2101877292 @default.
• W1994775902 cites W2102621484 @default.
• W1994775902 cites W2107295567 @default.
• W1994775902 cites W2109362406 @default.
• W1994775902 cites W2113324803 @default.
• W1994775902 cites W2119507799 @default.
• W1994775902 cites W2119711182 @default.
• W1994775902 cites W2119749825 @default.
• W1994775902 cites W2120676966 @default.
• W1994775902 cites W2121846158 @default.
• W1994775902 cites W2123089077 @default.
• W1994775902 cites W2123106337 @default.
• W1994775902 cites W2128098474 @default.
• W1994775902 cites W2130410032 @default.
• W1994775902 cites W2132496379 @default.
• W1994775902 cites W2135707527 @default.
• W1994775902 cites W2140248780 @default.
• W1994775902 cites W2140711896 @default.
• W1994775902 cites W2140850762 @default.
• W1994775902 cites W2142056290 @default.
• W1994775902 cites W2143178270 @default.
• W1994775902 cites W2149118697 @default.
• W1994775902 cites W2149920358 @default.
• W1994775902 cites W2152394730 @default.
• W1994775902 cites W2152727338 @default.

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