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• W1994787908 abstract "We studied conformational stability and folding kinetics of a three-stranded beta-sheet containing two rigid turns. Static infrared measurements indicate that this beta-sheet undergoes a broad but cooperative thermal unfolding transition with a midpoint at approximately 53 degrees C. Interestingly, time-resolved infrared experiments show that its relaxation kinetics in response to a temperature-jump (T-jump) occur on the nanosecond time scale (e.g., the relaxation time is approximately 140 ns at 35.0 degrees C), thereby suggesting that the conformational relaxation encounters only a small free energy barrier or even proceeds in a downhill manner. Further Langevin dynamics simulations suggest that the observed T-jump relaxation kinetics could be modeled by a conformational diffusion process along a single-well free energy profile, which allowed us to determine the effective diffusion constant and also the roughness of the folding energy landscape." @default.
• W1994787908 created "2016-06-24" @default.
• W1994787908 creator A5004998219 @default.
• W1994787908 creator A5015329154 @default.
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• W1994787908 date "2006-11-15" @default.
• W1994787908 modified "2023-10-17" @default.
• W1994787908 title "Nanosecond Folding Dynamics of a Three-Stranded β-Sheet" @default.
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• W1994787908 doi "https://doi.org/10.1021/ja064865+" @default.
• W1994787908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17147395" @default.
• W1994787908 hasPublicationYear "2006" @default.
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