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• W1994788512 abstract "Abstract Despite an increasing interest in neural stem cell (NSC) research, relatively little is known about the biochemical regulation of cell death pathways in these cells. We demonstrate here, using murine‐derived multipotent C17.2 NSCs, that cells undergo mitochondria‐mediated cell death in response to apoptotic stimuli such as oxidative stress induced by 2,3‐dimethoxy‐1,4‐naphthoquinone (DMNQ). In particular, treated cells exhibited apoptotic features, including Bax translocation, cytochrome c release, activation of caspase‐9 and ‐3, chromatin condensation and DNA fragmentation. Although C17.2 cells possess the Fas receptor and express procaspase‐8, agonistic Fas mAb treatment failed to induce apoptosis. Fas treatment activated the extracellular signal‐regulated protein kinase (ERK) pathway, which may have an antiapoptotic as well as a growth stimulating role. Combined, our findings indicate that while NSCs are sensitive to cytotoxic stimuli that involve an engagement of mitochondria, Fas treatment does not induce death and may have an alternative role." @default.
• W1994788512 created "2016-06-24" @default.
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• W1994788512 date "2004-05-01" @default.
• W1994788512 modified "2023-10-14" @default.
• W1994788512 title "Differential regulation of the mitochondrial and death receptor pathways in neural stem cells" @default.
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• W1994788512 doi "https://doi.org/10.1111/j.0953-816x.2004.03391.x" @default.
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