FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994788963> ?p ?o ?g. }

• W1994788963 endingPage "402" @default.
• W1994788963 startingPage "391" @default.
• W1994788963 abstract "microRNAs (miRs) are 18-25 nucleotide non-coding RNAs that regulate gene expression in several physiological and pathological conditions. To gather more knowledge on microRNAs in human hepatocellular carcinoma (HCC) we generated a small RNA library in the human HCC cell line HA22T/VGH by cloning and sequencing the cDNA obtained following the size selection of 18-24 nucleotide RNAs. We determined the expression levels of the most frequently cloned microRNAs by qPCR in HCC tissues and in their peritumoral counterparts from biopsy specimens of 41 HCC patients. The most frequently cloned miRs were miR-24, miR-27a and miR-21, and their expression levels in human HCC tissues indicate that these miRs were dysregulated in HCC. We showed that miR-24 and miR-27a were significantly downregulated in HCCs from cirrhotic liver tissues in comparison to those from non-cirrhotic liver tissues. In cirrhotic HCCs the downregulation of miR-24 was correlated with poorer prognosis in patients with HBV and HCV virus infections. miR-21 was generally upregulated in HCC tissues versus the corresponding peritumoral tissues, particularly in non-cirrhotic HCC. Furthermore, by sequence alignment we identified the human miR orthologue of Mus musculus miR-1199 not yet annotated. Our results outline the differential expression of miRs in cirrhotic and non-cirrhotic HCCs, thereby contributing to advances in the discovery and validation of novel molecular biomarkers of HCC progression." @default.
• W1994788963 created "2016-06-24" @default.
• W1994788963 creator A5012461540 @default.
• W1994788963 creator A5013063447 @default.
• W1994788963 creator A5029712854 @default.
• W1994788963 creator A5057939408 @default.
• W1994788963 creator A5072021164 @default.
• W1994788963 date "2012-11-28" @default.
• W1994788963 modified "2023-10-04" @default.
• W1994788963 title "Human hepatocellular carcinoma cell-specific miRNAs reveal the differential expression of miR-24 and miR-27a in cirrhotic/non-cirrhotic HCC" @default.
• W1994788963 cites W1966116761 @default.
• W1994788963 cites W1976029219 @default.
• W1994788963 cites W1989373617 @default.
• W1994788963 cites W2000093333 @default.
• W1994788963 cites W2002061154 @default.
• W1994788963 cites W2005139620 @default.
• W1994788963 cites W2007919766 @default.
• W1994788963 cites W2014771981 @default.
• W1994788963 cites W2017617041 @default.
• W1994788963 cites W2026936876 @default.
• W1994788963 cites W2028164074 @default.
• W1994788963 cites W2028687451 @default.
• W1994788963 cites W2029300527 @default.
• W1994788963 cites W2047119105 @default.
• W1994788963 cites W2047146433 @default.
• W1994788963 cites W2047438086 @default.
• W1994788963 cites W2048178760 @default.
• W1994788963 cites W2050099686 @default.
• W1994788963 cites W2051126469 @default.
• W1994788963 cites W2070571588 @default.
• W1994788963 cites W2073391234 @default.
• W1994788963 cites W2074664629 @default.
• W1994788963 cites W2085592081 @default.
• W1994788963 cites W2100084607 @default.
• W1994788963 cites W2100651747 @default.
• W1994788963 cites W2103211592 @default.
• W1994788963 cites W2103689264 @default.
• W1994788963 cites W2116147330 @default.
• W1994788963 cites W2119066197 @default.
• W1994788963 cites W2121629705 @default.
• W1994788963 cites W2123079914 @default.
• W1994788963 cites W2139791626 @default.
• W1994788963 cites W2144038313 @default.
• W1994788963 cites W2151922790 @default.
• W1994788963 cites W2161283857 @default.
• W1994788963 doi "https://doi.org/10.3892/ijo.2012.1716" @default.
• W1994788963 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3583619" @default.
• W1994788963 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23229173" @default.
• W1994788963 hasPublicationYear "2012" @default.
• W1994788963 type Work @default.
• W1994788963 sameAs 1994788963 @default.
• W1994788963 citedByCount "48" @default.
• W1994788963 countsByYear W19947889632013 @default.
• W1994788963 countsByYear W19947889632014 @default.
• W1994788963 countsByYear W19947889632015 @default.
• W1994788963 countsByYear W19947889632016 @default.
• W1994788963 countsByYear W19947889632017 @default.
• W1994788963 countsByYear W19947889632018 @default.
• W1994788963 countsByYear W19947889632019 @default.
• W1994788963 countsByYear W19947889632020 @default.
• W1994788963 countsByYear W19947889632022 @default.
• W1994788963 countsByYear W19947889632023 @default.
• W1994788963 crossrefType "journal-article" @default.
• W1994788963 hasAuthorship W1994788963A5012461540 @default.
• W1994788963 hasAuthorship W1994788963A5013063447 @default.
• W1994788963 hasAuthorship W1994788963A5029712854 @default.
• W1994788963 hasAuthorship W1994788963A5057939408 @default.
• W1994788963 hasAuthorship W1994788963A5072021164 @default.
• W1994788963 hasBestOaLocation W19947889631 @default.
• W1994788963 hasConcept C104317684 @default.
• W1994788963 hasConcept C126322002 @default.
• W1994788963 hasConcept C127561419 @default.
• W1994788963 hasConcept C142724271 @default.
• W1994788963 hasConcept C145059251 @default.
• W1994788963 hasConcept C150194340 @default.
• W1994788963 hasConcept C2777214474 @default.
• W1994788963 hasConcept C2778019345 @default.
• W1994788963 hasConcept C2779314089 @default.
• W1994788963 hasConcept C2781018059 @default.
• W1994788963 hasConcept C29537977 @default.
• W1994788963 hasConcept C502942594 @default.
• W1994788963 hasConcept C54355233 @default.
• W1994788963 hasConcept C71924100 @default.
• W1994788963 hasConcept C86803240 @default.
• W1994788963 hasConceptScore W1994788963C104317684 @default.
• W1994788963 hasConceptScore W1994788963C126322002 @default.
• W1994788963 hasConceptScore W1994788963C127561419 @default.
• W1994788963 hasConceptScore W1994788963C142724271 @default.
• W1994788963 hasConceptScore W1994788963C145059251 @default.
• W1994788963 hasConceptScore W1994788963C150194340 @default.
• W1994788963 hasConceptScore W1994788963C2777214474 @default.
• W1994788963 hasConceptScore W1994788963C2778019345 @default.
• W1994788963 hasConceptScore W1994788963C2779314089 @default.
• W1994788963 hasConceptScore W1994788963C2781018059 @default.
• W1994788963 hasConceptScore W1994788963C29537977 @default.
• W1994788963 hasConceptScore W1994788963C502942594 @default.
• W1994788963 hasConceptScore W1994788963C54355233 @default.
• W1994788963 hasConceptScore W1994788963C71924100 @default.

• next