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• W1994789488 abstract "Objective The effects of potent statins on oxidized lipoprotein biomarkers are not well defined. Methods and results The VISION (Value of oxIdant lipid lowering effect by Statin InterventiON in hypercholesterolemia) Trial randomized patients with hypercholesterolemia to 12-week administration of pitavastatin 2 mg/day (n = 21) or atorvastatin 10 mg/day (n = 21) and a variety of lipoprotein oxidative biomarkers were measured. Between-group analysis did not reveal any differences except in the ratio of malondialdehyde (MDA)-LDL over apolipoprotein B-100 (MDA-LDL/apoB) in pitavastatin vs. atorvastatin group (−13% vs. −0.7%, p = 0.04). Within-group changes from baseline to 12-week revealed significant increases in OxPL/apoB and reductions in small-dense LDL, MDA-LDL, and lipoprotein-associated phospholipase A2 measured on circulating apoB particles (Lp-PLA2/apoB) in both groups and significant reductions in OxPL/apoAI in the atorvastatin group. Conclusions The VISION study describes the first comparison on lipoprotein oxidation biomarkers between pitavastatin and atorvastatin and suggests diverse effects on lipoprotein oxidation markers in patients with hypercholesterolemia." @default.
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• W1994789488 date "2013-01-01" @default.
• W1994789488 modified "2023-09-25" @default.
• W1994789488 title "Effects of pitavastatin and atorvastatin on lipoprotein oxidation biomarkers in patients with dyslipidemia" @default.
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• W1994789488 doi "https://doi.org/10.1016/j.atherosclerosis.2012.10.069" @default.
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