Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994794562> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1994794562 endingPage "1743" @default.
- W1994794562 startingPage "1738" @default.
- W1994794562 abstract "Homologous up-regulation of somatostatin receptors (SSTR) was investigated in the GH3 clonal pituitary cell line. We report that chronic exposure to SRIF which has high affinity for all SSTR subtypes leads to a net increase in receptor binding and SSTR subtype mRNA. Treatment of cells with 1 μM SRIF increased specific [125I-Tyr11] SRIF binding to 280% of control values by 24 hr and to 350% by 48hr. Associated with the increase in SSTR binding was a net increase in SSTR subtype mRNA expression. Levels of SSTR1 increased to over 400% of control values by 6 hr and remaied elevated for up to 48 hr. SSTR3, SSTR4, and SSTR5 mRNA was also dramatically increased at 24 and 48 hr. SSTR2 mRNA, in contrast, showed a biphasic response, initially increasingly to 150% of control at 2 hr then decreasing to 50% at 6 hr with normalization by 48 hr. Our data suggests that multiple mechanisms contribute to the highly regulated expression of SSTR subtypes. The identification of specific molecular and cellular mechanisms mediating homologous SSTR up-regulation in GH3 cells and the involvement this process has in mediating the diverse biological effects of somatostatin are topics of current research." @default.
- W1994794562 created "2016-06-24" @default.
- W1994794562 creator A5011317474 @default.
- W1994794562 creator A5022146369 @default.
- W1994794562 creator A5042274161 @default.
- W1994794562 date "1994-08-01" @default.
- W1994794562 modified "2023-10-15" @default.
- W1994794562 title "Somatostatin Regulates Somatostatin Receptor Subtype mRNA Expression in GH3 Cells" @default.
- W1994794562 doi "https://doi.org/10.1006/bbrc.1994.2136" @default.
- W1994794562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7914724" @default.
- W1994794562 hasPublicationYear "1994" @default.
- W1994794562 type Work @default.
- W1994794562 sameAs 1994794562 @default.
- W1994794562 citedByCount "79" @default.
- W1994794562 countsByYear W19947945622012 @default.
- W1994794562 countsByYear W19947945622013 @default.
- W1994794562 countsByYear W19947945622014 @default.
- W1994794562 countsByYear W19947945622015 @default.
- W1994794562 countsByYear W19947945622016 @default.
- W1994794562 countsByYear W19947945622019 @default.
- W1994794562 countsByYear W19947945622023 @default.
- W1994794562 crossrefType "journal-article" @default.
- W1994794562 hasAuthorship W1994794562A5011317474 @default.
- W1994794562 hasAuthorship W1994794562A5022146369 @default.
- W1994794562 hasAuthorship W1994794562A5042274161 @default.
- W1994794562 hasConcept C104317684 @default.
- W1994794562 hasConcept C105580179 @default.
- W1994794562 hasConcept C126322002 @default.
- W1994794562 hasConcept C134018914 @default.
- W1994794562 hasConcept C150008808 @default.
- W1994794562 hasConcept C153911025 @default.
- W1994794562 hasConcept C170493617 @default.
- W1994794562 hasConcept C185592680 @default.
- W1994794562 hasConcept C2776297358 @default.
- W1994794562 hasConcept C32363146 @default.
- W1994794562 hasConcept C55493867 @default.
- W1994794562 hasConcept C64980429 @default.
- W1994794562 hasConcept C71924100 @default.
- W1994794562 hasConcept C80115893 @default.
- W1994794562 hasConcept C86803240 @default.
- W1994794562 hasConceptScore W1994794562C104317684 @default.
- W1994794562 hasConceptScore W1994794562C105580179 @default.
- W1994794562 hasConceptScore W1994794562C126322002 @default.
- W1994794562 hasConceptScore W1994794562C134018914 @default.
- W1994794562 hasConceptScore W1994794562C150008808 @default.
- W1994794562 hasConceptScore W1994794562C153911025 @default.
- W1994794562 hasConceptScore W1994794562C170493617 @default.
- W1994794562 hasConceptScore W1994794562C185592680 @default.
- W1994794562 hasConceptScore W1994794562C2776297358 @default.
- W1994794562 hasConceptScore W1994794562C32363146 @default.
- W1994794562 hasConceptScore W1994794562C55493867 @default.
- W1994794562 hasConceptScore W1994794562C64980429 @default.
- W1994794562 hasConceptScore W1994794562C71924100 @default.
- W1994794562 hasConceptScore W1994794562C80115893 @default.
- W1994794562 hasConceptScore W1994794562C86803240 @default.
- W1994794562 hasIssue "3" @default.
- W1994794562 hasLocation W19947945621 @default.
- W1994794562 hasLocation W19947945622 @default.
- W1994794562 hasOpenAccess W1994794562 @default.
- W1994794562 hasPrimaryLocation W19947945621 @default.
- W1994794562 hasRelatedWork W1741250325 @default.
- W1994794562 hasRelatedWork W2001169676 @default.
- W1994794562 hasRelatedWork W2018042027 @default.
- W1994794562 hasRelatedWork W2046702994 @default.
- W1994794562 hasRelatedWork W2118631824 @default.
- W1994794562 hasRelatedWork W2140741951 @default.
- W1994794562 hasRelatedWork W2413517490 @default.
- W1994794562 hasRelatedWork W2417605013 @default.
- W1994794562 hasRelatedWork W2472221713 @default.
- W1994794562 hasRelatedWork W597918840 @default.
- W1994794562 hasVolume "202" @default.
- W1994794562 isParatext "false" @default.
- W1994794562 isRetracted "false" @default.
- W1994794562 magId "1994794562" @default.
- W1994794562 workType "article" @default.