Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994804792> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W1994804792 abstract "The effects on malaria parasite growth of antisense and sense oligodeoxynucleoside phosphorothioates based on a merozoite surface protein mRNA was examined. Specific antisense effects of the oligonucleotides could not be demonstrated over three cycles of schizogony or when added as a complex with cationic liposomes. Antisense and sense oligonucleotides however, inhibit merozoite invasion of red blood cells at similar concentrations to dextran sulphate, a polyanion, as determined by microscopy and [3H]hypoxanthine incorporation into DNA. Neutralisation of the negative charge on the oligonucleotides by binding to cationic lipid liposomes, prevented the inhibition of merozoite invasion. We postulate that oligonucleotides because of their polyanionic nature interfere with the binding of merozoites to receptors on red blood cells and that polyanions may be useful in malaria therapy." @default.
- W1994804792 created "2016-06-24" @default.
- W1994804792 creator A5010359227 @default.
- W1994804792 creator A5014727376 @default.
- W1994804792 creator A5045866657 @default.
- W1994804792 creator A5056771831 @default.
- W1994804792 date "1998-09-01" @default.
- W1994804792 modified "2023-09-23" @default.
- W1994804792 title "Malaria merozoite surface protein antisense oligodeoxynucleotides lack antisense activity but function as polyanions to inhibit red cell invasion" @default.
- W1994804792 cites W1990548509 @default.
- W1994804792 cites W1990807584 @default.
- W1994804792 cites W1993733633 @default.
- W1994804792 cites W1996386742 @default.
- W1994804792 cites W2029365127 @default.
- W1994804792 cites W2044893539 @default.
- W1994804792 cites W2083126580 @default.
- W1994804792 cites W2085414969 @default.
- W1994804792 cites W2092737564 @default.
- W1994804792 cites W2094809928 @default.
- W1994804792 cites W2099742982 @default.
- W1994804792 cites W2136828884 @default.
- W1994804792 cites W2150532372 @default.
- W1994804792 cites W2302076618 @default.
- W1994804792 doi "https://doi.org/10.1016/s1357-2725(98)00051-x" @default.
- W1994804792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9785462" @default.
- W1994804792 hasPublicationYear "1998" @default.
- W1994804792 type Work @default.
- W1994804792 sameAs 1994804792 @default.
- W1994804792 citedByCount "13" @default.
- W1994804792 countsByYear W19948047922013 @default.
- W1994804792 countsByYear W19948047922014 @default.
- W1994804792 countsByYear W19948047922016 @default.
- W1994804792 crossrefType "journal-article" @default.
- W1994804792 hasAuthorship W1994804792A5010359227 @default.
- W1994804792 hasAuthorship W1994804792A5014727376 @default.
- W1994804792 hasAuthorship W1994804792A5045866657 @default.
- W1994804792 hasAuthorship W1994804792A5056771831 @default.
- W1994804792 hasConcept C104317684 @default.
- W1994804792 hasConcept C129312508 @default.
- W1994804792 hasConcept C143141573 @default.
- W1994804792 hasConcept C14363569 @default.
- W1994804792 hasConcept C147789679 @default.
- W1994804792 hasConcept C153911025 @default.
- W1994804792 hasConcept C155887181 @default.
- W1994804792 hasConcept C185154212 @default.
- W1994804792 hasConcept C185592680 @default.
- W1994804792 hasConcept C203014093 @default.
- W1994804792 hasConcept C2777023991 @default.
- W1994804792 hasConcept C2778048844 @default.
- W1994804792 hasConcept C2778371730 @default.
- W1994804792 hasConcept C2781034427 @default.
- W1994804792 hasConcept C2908938912 @default.
- W1994804792 hasConcept C54009773 @default.
- W1994804792 hasConcept C552990157 @default.
- W1994804792 hasConcept C55493867 @default.
- W1994804792 hasConcept C86803240 @default.
- W1994804792 hasConceptScore W1994804792C104317684 @default.
- W1994804792 hasConceptScore W1994804792C129312508 @default.
- W1994804792 hasConceptScore W1994804792C143141573 @default.
- W1994804792 hasConceptScore W1994804792C14363569 @default.
- W1994804792 hasConceptScore W1994804792C147789679 @default.
- W1994804792 hasConceptScore W1994804792C153911025 @default.
- W1994804792 hasConceptScore W1994804792C155887181 @default.
- W1994804792 hasConceptScore W1994804792C185154212 @default.
- W1994804792 hasConceptScore W1994804792C185592680 @default.
- W1994804792 hasConceptScore W1994804792C203014093 @default.
- W1994804792 hasConceptScore W1994804792C2777023991 @default.
- W1994804792 hasConceptScore W1994804792C2778048844 @default.
- W1994804792 hasConceptScore W1994804792C2778371730 @default.
- W1994804792 hasConceptScore W1994804792C2781034427 @default.
- W1994804792 hasConceptScore W1994804792C2908938912 @default.
- W1994804792 hasConceptScore W1994804792C54009773 @default.
- W1994804792 hasConceptScore W1994804792C552990157 @default.
- W1994804792 hasConceptScore W1994804792C55493867 @default.
- W1994804792 hasConceptScore W1994804792C86803240 @default.
- W1994804792 hasLocation W19948047921 @default.
- W1994804792 hasLocation W19948047922 @default.
- W1994804792 hasOpenAccess W1994804792 @default.
- W1994804792 hasPrimaryLocation W19948047921 @default.
- W1994804792 hasRelatedWork W1515776315 @default.
- W1994804792 hasRelatedWork W1994804792 @default.
- W1994804792 hasRelatedWork W2013140682 @default.
- W1994804792 hasRelatedWork W2039595469 @default.
- W1994804792 hasRelatedWork W2064861225 @default.
- W1994804792 hasRelatedWork W2090433719 @default.
- W1994804792 hasRelatedWork W2095908151 @default.
- W1994804792 hasRelatedWork W2163537252 @default.
- W1994804792 hasRelatedWork W2358205972 @default.
- W1994804792 hasRelatedWork W2189200247 @default.
- W1994804792 isParatext "false" @default.
- W1994804792 isRetracted "false" @default.
- W1994804792 magId "1994804792" @default.
- W1994804792 workType "article" @default.