FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994808726> ?p ?o ?g. }

• W1994808726 endingPage "e49856" @default.
• W1994808726 startingPage "e49856" @default.
• W1994808726 abstract "Influenza infection is a major cause of morbidity and mortality. Retinoic acid-inducible gene I (RIG-I) is believed to play an important role in the recognition of, and response to, influenza virus and other RNA viruses. Our study focuses on the hypothesis that pandemic H1N1/09 influenza virus alters the influenza-induced proinflammatory response and suppresses host antiviral activity. We first compared the innate response to a clinical isolate of influenza A(H1N1)pdm09 virus, OK/09, a clinical isolate of seasonal H3N2 virus, OK/06, and to a laboratory adapted seasonal H1N1 virus, PR8, using a unique human lung organ culture model. Exposure of human lung tissue to either pandemic or seasonal influenza virus resulted in infection and replication in alveolar epithelial cells. Pandemic virus induces a diminished RIG-I mRNA and antiviral cytokine response than seasonal virus in human lung. The suppression of antiviral response and RIG-I mRNA expression was confirmed at the protein level by ELISA and western blot. We performed a time course of RIG-I and interferon-β (IFN-β) mRNA induction by the two viruses. RIG-I and IFN-β induction by OK/09 was of lower amplitude and shorter duration than that caused by PR8. In contrast, the pandemic virus OK/09 caused similar induction of proinflammatory cytokines, IL-8 and IL-6, at both the transcriptional and translational level as PR8 in human lung. Differential antiviral responses did not appear to be due to a difference in cellular infectivity as immunohistochemistry showed that both viruses infected alveolar macrophages and epithelial cells. These findings show that influenza A(H1N1)pdm09 virus suppresses anti-viral immune responses in infected human lung through inhibition of viral-mediated induction of the pattern recognition receptor, RIG-I, though proinflammatory cytokine induction was unaltered. This immunosuppression of the host antiviral response by pandemic virus may have contributed to the more serious lung infections that occurred in the H1N1 pandemic of 2009." @default.
• W1994808726 created "2016-06-24" @default.
• W1994808726 creator A5007837296 @default.
• W1994808726 creator A5030911572 @default.
• W1994808726 creator A5046292905 @default.
• W1994808726 creator A5063252520 @default.
• W1994808726 date "2012-11-21" @default.
• W1994808726 modified "2023-10-07" @default.
• W1994808726 title "Influenza A(H1N1)pdm09 Virus Suppresses RIG-I Initiated Innate Antiviral Responses in the Human Lung" @default.
• W1994808726 cites W1489290087 @default.
• W1994808726 cites W1869071094 @default.
• W1994808726 cites W1970601906 @default.
• W1994808726 cites W1982648016 @default.
• W1994808726 cites W1994391392 @default.
• W1994808726 cites W1995061985 @default.
• W1994808726 cites W1996790111 @default.
• W1994808726 cites W2001484558 @default.
• W1994808726 cites W2007032789 @default.
• W1994808726 cites W2009127910 @default.
• W1994808726 cites W2014960200 @default.
• W1994808726 cites W2017348279 @default.
• W1994808726 cites W2028575270 @default.
• W1994808726 cites W2028642580 @default.
• W1994808726 cites W2035304200 @default.
• W1994808726 cites W2038834254 @default.
• W1994808726 cites W2041753380 @default.
• W1994808726 cites W2046950022 @default.
• W1994808726 cites W2047948762 @default.
• W1994808726 cites W2049989206 @default.
• W1994808726 cites W2057704272 @default.
• W1994808726 cites W2059717057 @default.
• W1994808726 cites W2061734037 @default.
• W1994808726 cites W2061868430 @default.
• W1994808726 cites W2068164971 @default.
• W1994808726 cites W2068592034 @default.
• W1994808726 cites W2071670416 @default.
• W1994808726 cites W2076165051 @default.
• W1994808726 cites W2093983981 @default.
• W1994808726 cites W2098349861 @default.
• W1994808726 cites W2098830790 @default.
• W1994808726 cites W2100624829 @default.
• W1994808726 cites W2102930999 @default.
• W1994808726 cites W2108620165 @default.
• W1994808726 cites W2110214166 @default.
• W1994808726 cites W2116775811 @default.
• W1994808726 cites W2121009566 @default.
• W1994808726 cites W2121593344 @default.
• W1994808726 cites W2123729021 @default.
• W1994808726 cites W2126623340 @default.
• W1994808726 cites W2133006561 @default.
• W1994808726 cites W2144148464 @default.
• W1994808726 cites W2149378058 @default.
• W1994808726 cites W2161208630 @default.
• W1994808726 cites W2163726366 @default.
• W1994808726 cites W2166835758 @default.
• W1994808726 cites W2317859204 @default.
• W1994808726 doi "https://doi.org/10.1371/journal.pone.0049856" @default.
• W1994808726 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3503992" @default.
• W1994808726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23185463" @default.
• W1994808726 hasPublicationYear "2012" @default.
• W1994808726 type Work @default.
• W1994808726 sameAs 1994808726 @default.
• W1994808726 citedByCount "27" @default.
• W1994808726 countsByYear W19948087262013 @default.
• W1994808726 countsByYear W19948087262014 @default.
• W1994808726 countsByYear W19948087262015 @default.
• W1994808726 countsByYear W19948087262016 @default.
• W1994808726 countsByYear W19948087262017 @default.
• W1994808726 countsByYear W19948087262018 @default.
• W1994808726 countsByYear W19948087262019 @default.
• W1994808726 countsByYear W19948087262020 @default.
• W1994808726 countsByYear W19948087262021 @default.
• W1994808726 countsByYear W19948087262022 @default.
• W1994808726 countsByYear W19948087262023 @default.
• W1994808726 crossrefType "journal-article" @default.
• W1994808726 hasAuthorship W1994808726A5007837296 @default.
• W1994808726 hasAuthorship W1994808726A5030911572 @default.
• W1994808726 hasAuthorship W1994808726A5046292905 @default.
• W1994808726 hasAuthorship W1994808726A5063252520 @default.
• W1994808726 hasBestOaLocation W19948087261 @default.
• W1994808726 hasConcept C136449434 @default.
• W1994808726 hasConcept C140704245 @default.
• W1994808726 hasConcept C159047783 @default.
• W1994808726 hasConcept C164027704 @default.
• W1994808726 hasConcept C203014093 @default.
• W1994808726 hasConcept C2522874641 @default.
• W1994808726 hasConcept C2776178377 @default.
• W1994808726 hasConcept C2776914184 @default.
• W1994808726 hasConcept C2776954689 @default.
• W1994808726 hasConcept C2777546802 @default.
• W1994808726 hasConcept C86803240 @default.
• W1994808726 hasConcept C8891405 @default.
• W1994808726 hasConceptScore W1994808726C136449434 @default.
• W1994808726 hasConceptScore W1994808726C140704245 @default.
• W1994808726 hasConceptScore W1994808726C159047783 @default.
• W1994808726 hasConceptScore W1994808726C164027704 @default.
• W1994808726 hasConceptScore W1994808726C203014093 @default.
• W1994808726 hasConceptScore W1994808726C2522874641 @default.

• next