Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994810155> ?p ?o ?g. }
- W1994810155 endingPage "15" @default.
- W1994810155 startingPage "1" @default.
- W1994810155 abstract "Chronic hepatitis C (CHC) is a serious medical problem necessitating more effective treatment. This study investigated the hypothesis that an induction approach with nIFN-beta for 24 weeks followed by PEG-IFN-alpha+ribavirin (standard of care: SOC) for 48 weeks (novel combination treatment: NCT) would increase the initial virologic response rate and restore innate and adaptive immune responses in CHC. Seven CHC patients with a high viral load and genotype 1b were treated with NCT. Serum cytokine and chemokine levels were evaluated during NCT. NCT prevented viral escape and breakthrough resulting in persistent viral clearance of HCVRNA. IL-15 was increased at the end of induction therapy in both early virologic responders (EAVRs) and late virologic responders (LAVRs); CXCL-8, CXCL-10, and CCL-4 levels were significantly decreased (<svg style=vertical-align:-0.30096pt;width:56.150002px; id=M1 height=11.25 version=1.1 viewBox=0 0 56.150002 11.25 width=56.150002 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,11.25)> <g transform=translate(72,-63)> <text transform=matrix(1,0,0,-1,-71.95,63.35)> <tspan style=font-size: 12.50px; x=0 y=0>𝑃</tspan> <tspan style=font-size: 12.50px; x=10.890113 y=0><</tspan> <tspan style=font-size: 12.50px; x=22.930502 y=0>0</tspan> <tspan style=font-size: 12.50px; x=29.182001 y=0>.</tspan> <tspan style=font-size: 12.50px; x=32.307751 y=0>0</tspan> <tspan style=font-size: 12.50px; x=38.559254 y=0>5</tspan> </text> </g> </g> </svg>) in EAVR but not in LAVR during NCT, and IL-12 increased significantly (<svg style=vertical-align:-0.30096pt;width:56.150002px; id=M2 height=11.25 version=1.1 viewBox=0 0 56.150002 11.25 width=56.150002 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,11.25)> <g transform=translate(72,-63)> <text transform=matrix(1,0,0,-1,-71.95,63.35)> <tspan style=font-size: 12.50px; x=0 y=0>𝑃</tspan> <tspan style=font-size: 12.50px; x=10.890113 y=0><</tspan> <tspan style=font-size: 12.50px; x=22.930502 y=0>0</tspan> <tspan style=font-size: 12.50px; x=29.182001 y=0>.</tspan> <tspan style=font-size: 12.50px; x=32.307751 y=0>0</tspan> <tspan style=font-size: 12.50px; x=38.559254 y=0>5</tspan> </text> </g> </g> </svg>) and CXCL-8 decreased significantly (<svg style=vertical-align:-0.30096pt;width:56.150002px; id=M3 height=11.25 version=1.1 viewBox=0 0 56.150002 11.25 width=56.150002 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,11.25)> <g transform=translate(72,-63)> <text transform=matrix(1,0,0,-1,-71.95,63.35)> <tspan style=font-size: 12.50px; x=0 y=0>𝑃</tspan> <tspan style=font-size: 12.50px; x=10.890113 y=0><</tspan> <tspan style=font-size: 12.50px; x=22.930502 y=0>0</tspan> <tspan style=font-size: 12.50px; x=29.182001 y=0>.</tspan> <tspan style=font-size: 12.50px; x=32.307751 y=0>0</tspan> <tspan style=font-size: 12.50px; x=38.559254 y=0>5</tspan> </text> </g> </g> </svg>) after the end of NCT in EAVR but not in LAVR. NCT prevented viral breakthrough with viral clearance leading to improvement of innate and adaptive immunity resulting in a sustained virologic response (SVR). NCT (<svg style=vertical-align:-0.17555pt;width:35.099998px; id=M4 height=10.9125 version=1.1 viewBox=0 0 35.099998 10.9125 width=35.099998 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,10.9125)> <g transform=translate(72,-63.27)> <text transform=matrix(1,0,0,-1,-71.95,63.5)> <tspan style=font-size: 12.50px; x=0 y=0>𝑛</tspan> <tspan style=font-size: 12.50px; x=9.6773224 y=0>=</tspan> <tspan style=font-size: 12.50px; x=21.71771 y=0>8</tspan> </text> </g> </g> </svg>) achieved a higher SVR rate than SOC (<svg style=vertical-align:-0.17555pt;width:35.099998px; id=M5 height=10.9125 version=1.1 viewBox=0 0 35.099998 10.9125 width=35.099998 xmlns=http://www.w3.org/2000/svg> <g transform=matrix(1.25,0,0,-1.25,0,10.9125)> <g transform=translate(72,-63.27)> <text transform=matrix(1,0,0,-1,-71.95,63.5)> <tspan style=font-size: 12.50px; x=0 y=0>𝑛</tspan> <tspan style=font-size: 12.50px; x=9.6773224 y=0>=</tspan> <tspan style=font-size: 12.50px; x=21.71771 y=0>8</tspan> </text> </g> </g> </svg>) in difficult-to-treat CHC patients with genotype 1 and high viral loads." @default.
- W1994810155 created "2016-06-24" @default.
- W1994810155 creator A5019370527 @default.
- W1994810155 creator A5027472824 @default.
- W1994810155 creator A5044789217 @default.
- W1994810155 creator A5054241519 @default.
- W1994810155 creator A5088114847 @default.
- W1994810155 creator A5020667025 @default.
- W1994810155 date "2012-01-01" @default.
- W1994810155 modified "2023-10-02" @default.
- W1994810155 title "Restoration of Innate and Adaptive Immune Responses by HCV Viral Inhibition with an Induction Approach Using Natural Interferon-Beta in Chronic Hepatitis C" @default.
- W1994810155 cites W1487135612 @default.
- W1994810155 cites W1633418194 @default.
- W1994810155 cites W1964322006 @default.
- W1994810155 cites W1967826472 @default.
- W1994810155 cites W1977764354 @default.
- W1994810155 cites W1981900811 @default.
- W1994810155 cites W1983948582 @default.
- W1994810155 cites W1987679698 @default.
- W1994810155 cites W1988325794 @default.
- W1994810155 cites W1991743610 @default.
- W1994810155 cites W1994710883 @default.
- W1994810155 cites W1997514631 @default.
- W1994810155 cites W2001360631 @default.
- W1994810155 cites W2005113160 @default.
- W1994810155 cites W2015199158 @default.
- W1994810155 cites W2017439081 @default.
- W1994810155 cites W2024086482 @default.
- W1994810155 cites W2028194374 @default.
- W1994810155 cites W2031913105 @default.
- W1994810155 cites W2034501752 @default.
- W1994810155 cites W2043703243 @default.
- W1994810155 cites W2043976325 @default.
- W1994810155 cites W2055846363 @default.
- W1994810155 cites W2078586740 @default.
- W1994810155 cites W2081342442 @default.
- W1994810155 cites W2085237060 @default.
- W1994810155 cites W2088948861 @default.
- W1994810155 cites W2098439946 @default.
- W1994810155 cites W2100797437 @default.
- W1994810155 cites W2102184637 @default.
- W1994810155 cites W2102232873 @default.
- W1994810155 cites W2102428015 @default.
- W1994810155 cites W2102554377 @default.
- W1994810155 cites W2106179331 @default.
- W1994810155 cites W2106232291 @default.
- W1994810155 cites W2106791445 @default.
- W1994810155 cites W2113864802 @default.
- W1994810155 cites W2119847512 @default.
- W1994810155 cites W2127040538 @default.
- W1994810155 cites W2127082703 @default.
- W1994810155 cites W2128705210 @default.
- W1994810155 cites W2143559032 @default.
- W1994810155 cites W2146313292 @default.
- W1994810155 cites W2146784433 @default.
- W1994810155 cites W2153346747 @default.
- W1994810155 cites W2162876988 @default.
- W1994810155 cites W4211077792 @default.
- W1994810155 doi "https://doi.org/10.1155/2012/582716" @default.
- W1994810155 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3433154" @default.
- W1994810155 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22966239" @default.
- W1994810155 hasPublicationYear "2012" @default.
- W1994810155 type Work @default.
- W1994810155 sameAs 1994810155 @default.
- W1994810155 citedByCount "5" @default.
- W1994810155 countsByYear W19948101552015 @default.
- W1994810155 countsByYear W19948101552016 @default.
- W1994810155 countsByYear W19948101552017 @default.
- W1994810155 countsByYear W19948101552019 @default.
- W1994810155 crossrefType "journal-article" @default.
- W1994810155 hasAuthorship W1994810155A5019370527 @default.
- W1994810155 hasAuthorship W1994810155A5020667025 @default.
- W1994810155 hasAuthorship W1994810155A5027472824 @default.
- W1994810155 hasAuthorship W1994810155A5044789217 @default.
- W1994810155 hasAuthorship W1994810155A5054241519 @default.
- W1994810155 hasAuthorship W1994810155A5088114847 @default.
- W1994810155 hasBestOaLocation W19948101551 @default.
- W1994810155 hasConcept C126322002 @default.
- W1994810155 hasConcept C13373296 @default.
- W1994810155 hasConcept C142462285 @default.
- W1994810155 hasConcept C159047783 @default.
- W1994810155 hasConcept C203014093 @default.
- W1994810155 hasConcept C2522874641 @default.
- W1994810155 hasConcept C2776178377 @default.
- W1994810155 hasConcept C2776408679 @default.
- W1994810155 hasConcept C2780040827 @default.
- W1994810155 hasConcept C2909179924 @default.
- W1994810155 hasConcept C71924100 @default.
- W1994810155 hasConcept C8891405 @default.
- W1994810155 hasConcept C90924648 @default.
- W1994810155 hasConceptScore W1994810155C126322002 @default.
- W1994810155 hasConceptScore W1994810155C13373296 @default.
- W1994810155 hasConceptScore W1994810155C142462285 @default.
- W1994810155 hasConceptScore W1994810155C159047783 @default.
- W1994810155 hasConceptScore W1994810155C203014093 @default.
- W1994810155 hasConceptScore W1994810155C2522874641 @default.
- W1994810155 hasConceptScore W1994810155C2776178377 @default.
- W1994810155 hasConceptScore W1994810155C2776408679 @default.