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- W1994817922 abstract "The promoting activity of polyamine analogs (IV ∼ XV) on staphylococcal nuclease with DNA as the substrate was compared with that of natural polyamines (I ∼ III): I NH2(CH2)3NH(CH2)4NH(CH2)3NH2 (spermine); II NH2(CH2)3NH(CH2)3NH(CH2)3NH2 (thermine); III NH2(CH2)4NH2 (putrescine); IV CN(CH2)2NH(CH2)4NH(CH2)2CN; V HOOC(CH2)2NH(CH2)4NH(CH2)2COOH; VI VI. C2H5OOC(CH2)2NH(CH2)4NH(CH2)2COOC2H5; VII VII. HO(CH2)3NH(CH2)4NH(CH2)3OH; VIII CH3CONH(CH2)3NH(CH2)4NH(CH2)3NHCOCH3; IX IX. C2H5NH(CH2)3NH(CH2)4NH(CH2)3NHC2H5; X NH2(CH2)3S(CH2)4S(CH2)3NH2; XI NH2(CH2)3NH(CH2)2O(CH2)2NH(CH2)3NH2; XII NH2(CH2)3NCH3(CH2)4NCH3(CH2)3NH2; XIII CN(CH2)2NCH3(CH2)4NCH3(CH2)2CN; XIV (CH3)2N(CH2)3NCH3(CH2)4NCH3(CH2)3N(CH3)2; XV NH2(CH2)2O(CH2)2NH2 Replacement of the terminal groups by CN, COOH, COOEt, NHAc, NHEt, or N(CH3)2 remarkably decreased the activity. The compound VII with terminal hydroxyl groups had a lower promoting activity at low concentrations, but revealed higher activity at higher concentrations and, in contrast to spermine, no inhibition at all even at very high concentrations. Replacement of both internal amino groups by sulfur or NCH3 decreased the activity. The introduction of an ether bond into the internal methylene groups (compound XI) highly decreased the activity. Based upon these findings the possible relationship between structure and activity is discussed." @default.
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- W1994817922 date "1976-01-01" @default.
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- W1994817922 title "Effects of polyamines and analogs on staphylococcal nuclease" @default.
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- W1994817922 doi "https://doi.org/10.1002/jobm.19760160807" @default.
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