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• W1994822723 abstract "The signaling activity of beta-catenin is thought to be regulated by phosphorylation of a cluster of N-terminal serines, putative sites for GSK3beta. In the prevailing model in the literature, GSK3beta-dependent phosphorylation of these sites targets beta-catenin for ubiquitin-mediated degradation. Wnt signaling inhibits GSK3beta activity and this blocks degradation, allowing beta-catenin to accumulate and signal. We show here that beta-catenin activity is not regulated solely by protein stability. Mutations in the putative GSK3beta phosphorylation sites of beta-catenin enhance its signaling activity, but this cannot be accounted for by accumulation of either total or cadherin-free protein. Instead, the mutant protein has a threefold higher specific activity than the wild type both in vivo and in an in vitro signaling assay. We conclude that the N-terminal serines convey a layer of regulation upon beta-catenin signaling in addition to the effects these sites exert upon protein stability." @default.
• W1994822723 created "2016-06-24" @default.
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• W1994822723 creator A5014081492 @default.
• W1994822723 date "2000-07-01" @default.
• W1994822723 modified "2023-09-23" @default.
• W1994822723 title "A Mode of Regulation of β-Catenin Signaling Activity in Xenopus Embryos Independent of Its Levels" @default.
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• W1994822723 doi "https://doi.org/10.1006/dbio.2000.9770" @default.
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