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• W1994825577 abstract "Objective: To test the hypothesis that ovarian hormones in women with hyperandrogenism alter adrenocortical steroidogenesis.Design: Combination of two prospective studies.Setting: Academic medical centers.Patient(s): Eighteen hyperandrogenic patients demonstrating hirsutism with either hyperandrogenemia, oligomenorrhea, or both. Eighteen healthy nonhirsute eumenorrheic untreated women served as controls.Interventions: Blood sampling basally and after acute adrenal stimulation with ACTH, before and after 20–24 weeks of leuprolide administration. Nine patients also received 0.625 mg/d of oral conjugated esterified estrogens and 10 mg of medroxyprogesterone acetate days 1–12 of the month (i.e., estrogen replacement therapy [ERT]), whereas the remaining nine did not.Main Outcome Measure(s): Before and after the administration of the GnRH agonist (GnRH-a), the basal concentrations of DHEAS; and the levels of androstenedione (A4), DHEA, androstenediol, 11β-hydroxyandrostenedione (11-OHA4), and cortisol before and 60 minutes after acute adrenal stimulation, were measured.Result(s): Levels of DHEAS, androstenediol, and 11-OHA4 decreased by 15%–30%, regardless of whether patients initially had or did not have DHEAS excess. However, only hyperandrogenic patients with elevated levels of DHEAS showed a significant decrease in basal DHEA levels. No statistically significant difference in the response of either androgen to ACTH (1-24) stimulation was noted with ovarian suppression, regardless of initial DHEAS level or use of ERT.Conclusion(s): We found no evidence that ovarian hormone secretion affected adrenal steroidogenesis, and those women with the highest adrenal androgen levels had the least response to GnRH-a suppression. These findings further support the concept of an intrinsic, and possibly primary, abnormality of adrenocortical steroidogenesis in a subset of hyperandrogenic women that is independent of ovarian abnormalities." @default.
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• W1994825577 date "1998-05-01" @default.
• W1994825577 modified "2023-10-18" @default.
• W1994825577 title "Role of the Ovary in the Adrenal Androgen Excess of Hyperandrogenic Women" @default.
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• W1994825577 doi "https://doi.org/10.1016/s0015-0282(98)00033-8" @default.
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