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- W1994835415 abstract "The spindle midzone—composed of antiparallel microtubules, microtubule-associated proteins (MAPs), and motors—is the structure responsible for microtubule organization and sliding during anaphase B. In general, MAPs and motors stabilize the midzone and motors produce sliding. We show that fission yeast kinesin-6 motor klp9p binds to the microtubule antiparallel bundler ase1p at the midzone at anaphase B onset. This interaction depends upon the phosphorylation states of klp9p and ase1p. The cyclin-dependent kinase cdc2p phosphorylates and its antagonist phosphatase clp1p dephosphorylates klp9p and ase1p to control the position and timing of klp9p-ase1p interaction. Failure of klp9p-ase1p binding leads to decreased spindle elongation velocity. The ase1p-mediated recruitment of klp9p to the midzone accelerates pole separation, as suggested by computer simulation. Our findings indicate that a phosphorylation switch controls the spatial-temporal interactions of motors and MAPs for proper anaphase B, and suggest a mechanism whereby a specific motor-MAP conformation enables efficient microtubule sliding." @default.
- W1994835415 created "2016-06-24" @default.
- W1994835415 creator A5007162733 @default.
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- W1994835415 date "2009-08-01" @default.
- W1994835415 modified "2023-10-07" @default.
- W1994835415 title "Phospho-Regulated Interaction between Kinesin-6 Klp9p and Microtubule Bundler Ase1p Promotes Spindle Elongation" @default.
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- W1994835415 cites W1484584251 @default.
- W1994835415 cites W1507388704 @default.
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- W1994835415 cites W1900541047 @default.
- W1994835415 cites W1906393634 @default.
- W1994835415 cites W1963750536 @default.
- W1994835415 cites W1966062268 @default.
- W1994835415 cites W1966571922 @default.
- W1994835415 cites W1973756205 @default.
- W1994835415 cites W1980145672 @default.
- W1994835415 cites W1980166711 @default.
- W1994835415 cites W1990565440 @default.
- W1994835415 cites W1992887353 @default.
- W1994835415 cites W1995749082 @default.
- W1994835415 cites W1999077006 @default.
- W1994835415 cites W2002367145 @default.
- W1994835415 cites W2005525594 @default.
- W1994835415 cites W2008852196 @default.
- W1994835415 cites W2010554051 @default.
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- W1994835415 doi "https://doi.org/10.1016/j.devcel.2009.06.012" @default.
- W1994835415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2997714" @default.
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