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- W1994838415 abstract "Robson & Adler [1940] have demonstrated that oestradiol, diethylstilboestrol and oestriol glucuronide can act locally without absorption into the general circulation. This they did by an ingenious technique, using spayed mice in which the vagina had been separated into two distinct pouches, a blind sac formed from the lower vagina, with the normal opening, and an upper vaginal sac with a suprapubic opening. When the oestrogens were given into the lumen of the upper vagina, this sac alone responded, while the lower vagina was not significantly affected. Even as much as 0·2μg. of diethylstilboestrol placed in the upper vagina failed to affect the lower vagina. It has now been shown that oestrogens are of two kinds. The true oestrogens are those which produce vaginal cornification in minute doses when given intravaginally, relative to the amounts needed by subcutaneous injection, whereas other oestrogenic compounds, the pro-oestrogens, must be given into the" @default.
- W1994838415 created "2016-06-24" @default.
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- W1994838415 date "1942-03-01" @default.
- W1994838415 modified "2023-10-05" @default.
- W1994838415 title "THE DIFFERENTIATION OF OESTROGENS FROM PRO-OESTROGENS BY THE USE OF SPAYED MICE POSSESSING TWO SEPARATE VAGINAL SACS" @default.
- W1994838415 doi "https://doi.org/10.1677/joe.0.0030174" @default.
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