FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994840580> ?p ?o ?g. }

• W1994840580 endingPage "6483" @default.
• W1994840580 startingPage "6473" @default.
• W1994840580 abstract "Cidofovir (CDV) is an U.S. Food and Drug Administration (FDA)-approved nucleoside antiviral agent used to treat severe human cytomegalovirus (HCMV) infection. Until now, no clear therapeutic effects of CDV have been reported outside of the setting of viral infection, including a potential role for CDV as an antineoplastic agent for the treatment of brain tumors.We investigated the cytotoxicity of CDV against the glioblastoma cells, U87MG and primary SF7796, both in vitro and in vivo, using an intracranial xenograft model. Standard techniques for cell culturing, immunohistochemistry, Western blotting, and real-time PCR were employed. The survival of athymic mice (n = 8-10 per group) bearing glioblastoma tumors, treated with CDV alone or in combination with radiation, was analyzed by the Kaplan-Meier method and evaluated with a two-sided log-rank test.CDV possesses potent antineoplastic activity against HCMV-infected glioblastoma cells. This activity is associated with the inhibition of HCMV gene expression and with activation of cellular apoptosis. Surprisingly, we also determined that CDV induces glioblastoma cell death in the absence of HCMV infection. CDV is incorporated into tumor cell DNA, which promotes double-stranded DNA breaks and induces apoptosis. In the setting of ionizing radiotherapy, the standard of care for glioblastoma in humans, CDV augments radiation-induced DNA damage and, further, promotes tumor cell death. Combination therapy with CDV and radiotherapy significantly extended the survival of mice bearing intracranial glioblastoma tumors.We have identified a novel antiglioma property of the FDA-approved drug CDV, which heightens the cytotoxic effect of radiotherapy, the standard of care therapy for glioblastoma." @default.
• W1994840580 created "2016-06-24" @default.
• W1994840580 creator A5003799255 @default.
• W1994840580 creator A5009060794 @default.
• W1994840580 creator A5009887167 @default.
• W1994840580 creator A5019173998 @default.
• W1994840580 creator A5026980145 @default.
• W1994840580 creator A5032510593 @default.
• W1994840580 creator A5047028132 @default.
• W1994840580 creator A5083860351 @default.
• W1994840580 creator A5087731653 @default.
• W1994840580 date "2013-12-01" @default.
• W1994840580 modified "2023-10-14" @default.
• W1994840580 title "Cidofovir: A Novel Antitumor Agent for Glioblastoma" @default.
• W1994840580 cites W1500300692 @default.
• W1994840580 cites W1977524040 @default.
• W1994840580 cites W1980416381 @default.
• W1994840580 cites W2014877570 @default.
• W1994840580 cites W2020723426 @default.
• W1994840580 cites W2022976025 @default.
• W1994840580 cites W2029620883 @default.
• W1994840580 cites W2030086454 @default.
• W1994840580 cites W2036570804 @default.
• W1994840580 cites W2038921550 @default.
• W1994840580 cites W2042389250 @default.
• W1994840580 cites W2042987981 @default.
• W1994840580 cites W2043072569 @default.
• W1994840580 cites W2058344604 @default.
• W1994840580 cites W2060360125 @default.
• W1994840580 cites W2062597360 @default.
• W1994840580 cites W2077760445 @default.
• W1994840580 cites W2091817354 @default.
• W1994840580 cites W2101560397 @default.
• W1994840580 cites W2106305381 @default.
• W1994840580 cites W2110136609 @default.
• W1994840580 cites W2110169557 @default.
• W1994840580 cites W2110265246 @default.
• W1994840580 cites W2114119309 @default.
• W1994840580 cites W2117134953 @default.
• W1994840580 cites W2133853290 @default.
• W1994840580 cites W2135135575 @default.
• W1994840580 cites W2136143258 @default.
• W1994840580 cites W2153620197 @default.
• W1994840580 cites W2154923857 @default.
• W1994840580 cites W2162417913 @default.
• W1994840580 cites W2169058303 @default.
• W1994840580 cites W2315706718 @default.
• W1994840580 cites W2316912275 @default.
• W1994840580 cites W2318744452 @default.
• W1994840580 doi "https://doi.org/10.1158/1078-0432.ccr-13-1121" @default.
• W1994840580 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3919795" @default.
• W1994840580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24170543" @default.
• W1994840580 hasPublicationYear "2013" @default.
• W1994840580 type Work @default.
• W1994840580 sameAs 1994840580 @default.
• W1994840580 citedByCount "55" @default.
• W1994840580 countsByYear W19948405802014 @default.
• W1994840580 countsByYear W19948405802015 @default.
• W1994840580 countsByYear W19948405802016 @default.
• W1994840580 countsByYear W19948405802017 @default.
• W1994840580 countsByYear W19948405802018 @default.
• W1994840580 countsByYear W19948405802019 @default.
• W1994840580 countsByYear W19948405802020 @default.
• W1994840580 countsByYear W19948405802021 @default.
• W1994840580 countsByYear W19948405802022 @default.
• W1994840580 countsByYear W19948405802023 @default.
• W1994840580 crossrefType "journal-article" @default.
• W1994840580 hasAuthorship W1994840580A5003799255 @default.
• W1994840580 hasAuthorship W1994840580A5009060794 @default.
• W1994840580 hasAuthorship W1994840580A5009887167 @default.
• W1994840580 hasAuthorship W1994840580A5019173998 @default.
• W1994840580 hasAuthorship W1994840580A5026980145 @default.
• W1994840580 hasAuthorship W1994840580A5032510593 @default.
• W1994840580 hasAuthorship W1994840580A5047028132 @default.
• W1994840580 hasAuthorship W1994840580A5083860351 @default.
• W1994840580 hasAuthorship W1994840580A5087731653 @default.
• W1994840580 hasBestOaLocation W19948405801 @default.
• W1994840580 hasConcept C109316439 @default.
• W1994840580 hasConcept C126322002 @default.
• W1994840580 hasConcept C128473837 @default.
• W1994840580 hasConcept C150903083 @default.
• W1994840580 hasConcept C159047783 @default.
• W1994840580 hasConcept C190283241 @default.
• W1994840580 hasConcept C202751555 @default.
• W1994840580 hasConcept C207001950 @default.
• W1994840580 hasConcept C2522874641 @default.
• W1994840580 hasConcept C2776543447 @default.
• W1994840580 hasConcept C2776824251 @default.
• W1994840580 hasConcept C2777333352 @default.
• W1994840580 hasConcept C2777389519 @default.
• W1994840580 hasConcept C2778227246 @default.
• W1994840580 hasConcept C31573885 @default.
• W1994840580 hasConcept C502942594 @default.
• W1994840580 hasConcept C509974204 @default.
• W1994840580 hasConcept C55493867 @default.
• W1994840580 hasConcept C71924100 @default.
• W1994840580 hasConcept C86803240 @default.
• W1994840580 hasConceptScore W1994840580C109316439 @default.

• next