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- W1994844171 abstract "Abstract: Prion diseases are neurodegenerative disorders associatedwith a conformational change in the normal cellular isoform of the prionprotein, PrPC, to an abnormal scrapie isoform, PrPSC.Unlike the α-helical PrPC, the protease-resistant core ofPrPSC is predominantly β-sheet and possesses a tendency topolymerize into amyloid fibrils. We performed experiments with two synthetichuman prion peptides, PrP(106-126) and PrP(127-147), to determine how peptidestructure affects neurotoxicity and protein-membrane interactions. Peptidesolutions possessing β-sheet and amyloid structures were neurotoxic toPC12 cells in vitro and bound with measurable affinities to cholesterol-richphospholipid membranes at ambient conditions, but peptide solutions lackingstable β-sheet structures and amyloid content were nontoxic and possessedless than one tenth of the binding affinities of the amyloid-containingpeptides. Regardless of structure, the peptide binding affinities tocholesterol-depleted membranes were greatly reduced. These results suggestthat the β-sheet and amyloid structures of the prion peptides give riseto their toxicity and membrane binding affinities and that membrane bindingaffinity, especially in cholesterol-rich environments, may be related totoxicity. Our results may have significance in understanding the role of thefibrillogenic cerebral deposits associated with some of the prion diseases inneurodegeneration and may have implications for other amyloidoses." @default.
- W1994844171 created "2016-06-24" @default.
- W1994844171 creator A5005972170 @default.
- W1994844171 creator A5060856893 @default.
- W1994844171 date "2008-07-29" @default.
- W1994844171 modified "2023-09-25" @default.
- W1994844171 title "The Role of Prion Peptide Structure and Aggregation in Toxicity and Membrane Binding" @default.
- W1994844171 cites W1480950303 @default.
- W1994844171 cites W1504267511 @default.
- W1994844171 cites W1566848521 @default.
- W1994844171 cites W1581477304 @default.
- W1994844171 cites W1592250997 @default.
- W1994844171 cites W1960543132 @default.
- W1994844171 cites W1967064045 @default.
- W1994844171 cites W1972409470 @default.
- W1994844171 cites W1973758214 @default.
- W1994844171 cites W1978827571 @default.
- W1994844171 cites W1979643175 @default.
- W1994844171 cites W1980082404 @default.
- W1994844171 cites W1981570625 @default.
- W1994844171 cites W1982188419 @default.
- W1994844171 cites W1983750916 @default.
- W1994844171 cites W1984266565 @default.
- W1994844171 cites W1988352449 @default.
- W1994844171 cites W1991436339 @default.
- W1994844171 cites W1992599971 @default.
- W1994844171 cites W2000769077 @default.
- W1994844171 cites W2005687845 @default.
- W1994844171 cites W2005848422 @default.
- W1994844171 cites W2006128671 @default.
- W1994844171 cites W2008982860 @default.
- W1994844171 cites W2010779625 @default.
- W1994844171 cites W2011606718 @default.
- W1994844171 cites W2013287099 @default.
- W1994844171 cites W2013679718 @default.
- W1994844171 cites W2015519486 @default.
- W1994844171 cites W2016166584 @default.
- W1994844171 cites W2017199541 @default.
- W1994844171 cites W2022392367 @default.
- W1994844171 cites W2026534774 @default.
- W1994844171 cites W2026582002 @default.
- W1994844171 cites W2028295349 @default.
- W1994844171 cites W2029440340 @default.
- W1994844171 cites W2032069891 @default.
- W1994844171 cites W2032379145 @default.
- W1994844171 cites W2033933409 @default.
- W1994844171 cites W2037491812 @default.
- W1994844171 cites W2042007687 @default.
- W1994844171 cites W2043400793 @default.
- W1994844171 cites W2046423700 @default.
- W1994844171 cites W2046784147 @default.
- W1994844171 cites W2049103748 @default.
- W1994844171 cites W2050407809 @default.
- W1994844171 cites W2052234415 @default.
- W1994844171 cites W2054389100 @default.
- W1994844171 cites W2056939343 @default.
- W1994844171 cites W2057714820 @default.
- W1994844171 cites W2058659733 @default.
- W1994844171 cites W2059804089 @default.
- W1994844171 cites W2061301953 @default.
- W1994844171 cites W2072244190 @default.
- W1994844171 cites W2073699804 @default.
- W1994844171 cites W2079564988 @default.
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- W1994844171 cites W2094337931 @default.
- W1994844171 cites W2106306100 @default.
- W1994844171 cites W2109401365 @default.
- W1994844171 cites W2138608071 @default.
- W1994844171 cites W2138768135 @default.
- W1994844171 cites W2143797894 @default.
- W1994844171 cites W2152278845 @default.
- W1994844171 cites W2165021720 @default.
- W1994844171 cites W2169950734 @default.
- W1994844171 cites W2258822090 @default.
- W1994844171 cites W2315605170 @default.
- W1994844171 cites W2340182873 @default.
- W1994844171 cites W2419111026 @default.
- W1994844171 cites W4235120663 @default.
- W1994844171 cites W4239578974 @default.
- W1994844171 cites W4246293002 @default.
- W1994844171 cites W4296154147 @default.
- W1994844171 doi "https://doi.org/10.1046/j.1471-4159.2000.0752536.x" @default.
- W1994844171 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11080207" @default.
- W1994844171 hasPublicationYear "2008" @default.
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