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- W1994844765 abstract "This study evaluated in vitro binding of dopamine ligands to myometrial alpha adrenoceptors. With cell membranes from pregnant rabbits, receptor radioligand binding studies utilizing [3H] dihydroergocryptine +/- dopamine demonstrated receptor affinity (KD) = 0.75 +/- 0.10 nM (+/- SEM) and density (Bmax) = 533.2 +/- 45.2 fM/mg protein. Similar studies utilizing phentolamine or apomorphine gave essentially identical results. Competition binding studies demonstrated steriospecific butaclamol binding, along with significant binding of haloperidol, spiperone, apomorphine, and bromoergocryptine. These observations provide a mechanism for the observed uterotonic effects of dopamine." @default.
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- W1994844765 date "1987-02-01" @default.
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- W1994844765 title "Dopamine binding to the alpha receptor in pregnant rabbit myometrium" @default.
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- W1994844765 doi "https://doi.org/10.1016/0006-291x(87)91505-1" @default.
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