FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994846114> ?p ?o ?g. }

• W1994846114 endingPage "1174" @default.
• W1994846114 startingPage "1169" @default.
• W1994846114 abstract "Wiskott‑Aldrich syndrome protein family member 3 (WASF3) is required for invasion and metastasis in different cancer cell types, and has been demonstrated to possess prognostic value in various types of human cancer. However, to the best of our knowledge, the expression profile of WASF3 and its correlations with the clinicopathological features of non‑small cell lung cancer (NSCLC) have not yet been described. In the present study, the mRNA expression levels of WASF3, in 38 NSCLC patients and in matched normal tissues, were assessed using quantitative polymerase chain reaction and the protein expression in 96 specimens was analyzed using immunohistochemistry. In addition, patient survival data were collected retrospectively and the association between WASF3 expression and five‑year overall survival was evaluated. The results demonstrated that the mRNA expression level of WASF3 in cancer tissues was markedly (approximately five times) higher compared with that of the normal tissues. The WASF3 protein expression profile in NSCLC was consistent with the mRNA expression result, which also correlated with the histological subtype and tumor stage. Furthermore, patients with WASF3‑positive expression were associated with a poorer prognosis compared with those exhibiting WASF3‑negative expression, and the five‑year survival rate was 20.8 and 46.5%, respectively (Kaplan‑Meier; log‑rank, P=0.004). In the multivariate analysis, which included other clinicopathological features, WASF3 emerged as an independent prognostic factor (relative risk, 0.463; 95% CI, 0.271‑0.792). These results indicate that WASF3 may be critical in the pathogenesis of NSCLC, in addition to being a valuable prognostic factor for NSCLC patients. Further investigations are required to identify the efficacy of WASF3 as a potential therapeutic target for the treatment of NSCLC." @default.
• W1994846114 created "2016-06-24" @default.
• W1994846114 creator A5054138047 @default.
• W1994846114 creator A5058624970 @default.
• W1994846114 creator A5081290307 @default.
• W1994846114 creator A5084886203 @default.
• W1994846114 date "2014-06-23" @default.
• W1994846114 modified "2023-09-27" @default.
• W1994846114 title "Expression of WASF3 in patients with non-small cell lung cancer: Correlation with clinicopathological features and prognosis" @default.
• W1994846114 cites W1535419937 @default.
• W1994846114 cites W1967557518 @default.
• W1994846114 cites W1986735026 @default.
• W1994846114 cites W1989343487 @default.
• W1994846114 cites W1992546178 @default.
• W1994846114 cites W2010843256 @default.
• W1994846114 cites W2013480667 @default.
• W1994846114 cites W2014565114 @default.
• W1994846114 cites W2019590129 @default.
• W1994846114 cites W2028826862 @default.
• W1994846114 cites W2036525893 @default.
• W1994846114 cites W2062249523 @default.
• W1994846114 cites W2063220206 @default.
• W1994846114 cites W2084296544 @default.
• W1994846114 cites W2084472730 @default.
• W1994846114 cites W2088120315 @default.
• W1994846114 cites W2089370460 @default.
• W1994846114 cites W2092180337 @default.
• W1994846114 cites W2102761045 @default.
• W1994846114 cites W2107277218 @default.
• W1994846114 cites W2115095574 @default.
• W1994846114 cites W2121034339 @default.
• W1994846114 cites W2126496496 @default.
• W1994846114 cites W2132244436 @default.
• W1994846114 cites W2139689863 @default.
• W1994846114 cites W2159755129 @default.
• W1994846114 cites W2164282019 @default.
• W1994846114 cites W2167626784 @default.
• W1994846114 cites W2329587797 @default.
• W1994846114 doi "https://doi.org/10.3892/ol.2014.2276" @default.
• W1994846114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4114608" @default.
• W1994846114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25120680" @default.
• W1994846114 hasPublicationYear "2014" @default.
• W1994846114 type Work @default.
• W1994846114 sameAs 1994846114 @default.
• W1994846114 citedByCount "11" @default.
• W1994846114 countsByYear W19948461142016 @default.
• W1994846114 countsByYear W19948461142019 @default.
• W1994846114 countsByYear W19948461142020 @default.
• W1994846114 countsByYear W19948461142021 @default.
• W1994846114 countsByYear W19948461142022 @default.
• W1994846114 countsByYear W19948461142023 @default.
• W1994846114 crossrefType "journal-article" @default.
• W1994846114 hasAuthorship W1994846114A5054138047 @default.
• W1994846114 hasAuthorship W1994846114A5058624970 @default.
• W1994846114 hasAuthorship W1994846114A5081290307 @default.
• W1994846114 hasAuthorship W1994846114A5084886203 @default.
• W1994846114 hasBestOaLocation W19948461141 @default.
• W1994846114 hasConcept C104317684 @default.
• W1994846114 hasConcept C10515644 @default.
• W1994846114 hasConcept C121608353 @default.
• W1994846114 hasConcept C126322002 @default.
• W1994846114 hasConcept C142724271 @default.
• W1994846114 hasConcept C143998085 @default.
• W1994846114 hasConcept C146357865 @default.
• W1994846114 hasConcept C1491633281 @default.
• W1994846114 hasConcept C151730666 @default.
• W1994846114 hasConcept C204232928 @default.
• W1994846114 hasConcept C2776256026 @default.
• W1994846114 hasConcept C2776283816 @default.
• W1994846114 hasConcept C2779013556 @default.
• W1994846114 hasConcept C2781018059 @default.
• W1994846114 hasConcept C29537977 @default.
• W1994846114 hasConcept C48023723 @default.
• W1994846114 hasConcept C54355233 @default.
• W1994846114 hasConcept C55493867 @default.
• W1994846114 hasConcept C67082663 @default.
• W1994846114 hasConcept C71924100 @default.
• W1994846114 hasConcept C86803240 @default.
• W1994846114 hasConceptScore W1994846114C104317684 @default.
• W1994846114 hasConceptScore W1994846114C10515644 @default.
• W1994846114 hasConceptScore W1994846114C121608353 @default.
• W1994846114 hasConceptScore W1994846114C126322002 @default.
• W1994846114 hasConceptScore W1994846114C142724271 @default.
• W1994846114 hasConceptScore W1994846114C143998085 @default.
• W1994846114 hasConceptScore W1994846114C146357865 @default.
• W1994846114 hasConceptScore W1994846114C1491633281 @default.
• W1994846114 hasConceptScore W1994846114C151730666 @default.
• W1994846114 hasConceptScore W1994846114C204232928 @default.
• W1994846114 hasConceptScore W1994846114C2776256026 @default.
• W1994846114 hasConceptScore W1994846114C2776283816 @default.
• W1994846114 hasConceptScore W1994846114C2779013556 @default.
• W1994846114 hasConceptScore W1994846114C2781018059 @default.
• W1994846114 hasConceptScore W1994846114C29537977 @default.
• W1994846114 hasConceptScore W1994846114C48023723 @default.
• W1994846114 hasConceptScore W1994846114C54355233 @default.
• W1994846114 hasConceptScore W1994846114C55493867 @default.
• W1994846114 hasConceptScore W1994846114C67082663 @default.
• W1994846114 hasConceptScore W1994846114C71924100 @default.

• next