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• W1994847566 endingPage "012006" @default.
• W1994847566 startingPage "012006" @default.
• W1994847566 abstract "The use of heavy compounds to enhance radiation induced damage is a promising approach to improve the therapeutic index of radiotherapy. In order to quantify and control the effects of these radiosensitizers, it is of fundamental interest to describe the elementary processes which take place at the molecular level. Using DNA as a probe, we present a comparison of the damage induced in the presence of platinum compounds exposed to different types of ionizing radiation. We present the results obtained with gamma rays (Linear Energy Transfer (LET) = 0.2 keV.μm−1), fast helium ions He2+ (LET = 2.3 keV.μm−1) and fast carbon ions C6+ (LET = 13 keV.μm−1 and LET = 110 keV.μm−1). The efficiency of two different sensitizers was measured: platinum based molecules (the chloroterpyridine platinum - PtTC) and platinum nanoparticles (PtNP). These experiments show that the two sensitizers are efficiently amplifying molecular damage under photon or ion irradiation. Experiments with a radical scavenger confirmed that these damages are mediated by free radicals for more than 90%. More interestingly, the induction of complex damage, the most lethal for the cells, is amplified by a factor of 1.5 on average if platinum (PtTC and PtNP) is present. As already known, the induction of complex damages increases also with the radiation LET. So, finally, the most significant enhancement of complex damage is observed when ion radiation is combined with platinum induced sensitization." @default.
• W1994847566 created "2016-06-24" @default.
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• W1994847566 date "2012-07-02" @default.
• W1994847566 modified "2023-10-18" @default.
• W1994847566 title "Nano-Sensitization under gamma rays and fast ion radiation" @default.
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• W1994847566 doi "https://doi.org/10.1088/1742-6596/373/1/012006" @default.
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