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- W1994861432 endingPage "623" @default.
- W1994861432 startingPage "603" @default.
- W1994861432 abstract "Drug resistance has always been a concern in cancer treatment, often blamed on the genetic complexity and instability of tumor cells. While studies of cancer cell lines have implicated an array of potential mechanisms, it has been difficult to translate these insights into clinically meaningful improvements in cancer treatment. The successful deployment of molecularly targeted therapeutics in some cancers has led to widespread optimism that this approach will become broadly applicable. Despite their early promise in the clinic, the novel therapeutics are often plagued with the age old problem of acquired drug resistance. Progress in understanding why certain patients respond and why some develop resistance can be made rapidly through studies of the drug target in tumor tissue from patient. One important lesson is that many cancers, even in the most advanced stages, continue to rely on a limited number of critical oncogenic signals for maintenance of the malignant phenotype. This article reviews the mechanisms of drug resistance to a variety of cancer therapeutics and provides an approach for how measures of drug target activity can be incorporated into clinical trial design." @default.
- W1994861432 created "2016-06-24" @default.
- W1994861432 creator A5020324479 @default.
- W1994861432 creator A5034963668 @default.
- W1994861432 date "2002-09-01" @default.
- W1994861432 modified "2023-09-26" @default.
- W1994861432 title "The emergence of resistance to targeted cancer therapeutics" @default.
- W1994861432 cites W116308216 @default.
- W1994861432 cites W120419820 @default.
- W1994861432 cites W1256525631 @default.
- W1994861432 cites W1483388049 @default.
- W1994861432 cites W1484817497 @default.
- W1994861432 cites W1485133218 @default.
- W1994861432 cites W1486948598 @default.
- W1994861432 cites W1487506158 @default.
- W1994861432 cites W1489284756 @default.
- W1994861432 cites W1509965873 @default.
- W1994861432 cites W1533153036 @default.
- W1994861432 cites W1542216061 @default.
- W1994861432 cites W1550565578 @default.
- W1994861432 cites W1551972473 @default.
- W1994861432 cites W1554600230 @default.
- W1994861432 cites W1560690111 @default.
- W1994861432 cites W1577381167 @default.
- W1994861432 cites W1580523172 @default.
- W1994861432 cites W1596051841 @default.
- W1994861432 cites W1603879531 @default.
- W1994861432 cites W1650797637 @default.
- W1994861432 cites W1651215666 @default.
- W1994861432 cites W1662819364 @default.
- W1994861432 cites W1750460473 @default.
- W1994861432 cites W1752169014 @default.
- W1994861432 cites W1804726264 @default.
- W1994861432 cites W1850914599 @default.
- W1994861432 cites W186063976 @default.
- W1994861432 cites W1909732837 @default.
- W1994861432 cites W1924607323 @default.
- W1994861432 cites W1931891535 @default.
- W1994861432 cites W1964767469 @default.
- W1994861432 cites W1968953597 @default.
- W1994861432 cites W1970042886 @default.
- W1994861432 cites W1970726343 @default.
- W1994861432 cites W1972304655 @default.
- W1994861432 cites W1972804480 @default.
- W1994861432 cites W1973109581 @default.
- W1994861432 cites W1973577899 @default.
- W1994861432 cites W1975336660 @default.
- W1994861432 cites W1975555167 @default.
- W1994861432 cites W1977499961 @default.
- W1994861432 cites W1977662716 @default.
- W1994861432 cites W1978480779 @default.
- W1994861432 cites W1979319210 @default.
- W1994861432 cites W1981044274 @default.
- W1994861432 cites W1981104809 @default.
- W1994861432 cites W1982097971 @default.
- W1994861432 cites W1982342754 @default.
- W1994861432 cites W1983547790 @default.
- W1994861432 cites W1984547206 @default.
- W1994861432 cites W1985044394 @default.
- W1994861432 cites W1985827132 @default.
- W1994861432 cites W1988609792 @default.
- W1994861432 cites W1988679331 @default.
- W1994861432 cites W1990161819 @default.
- W1994861432 cites W1995926826 @default.
- W1994861432 cites W1995930366 @default.
- W1994861432 cites W1996949194 @default.
- W1994861432 cites W1998038367 @default.
- W1994861432 cites W1999614615 @default.
- W1994861432 cites W1999932299 @default.
- W1994861432 cites W2005873549 @default.
- W1994861432 cites W2006434892 @default.
- W1994861432 cites W2006518962 @default.
- W1994861432 cites W2006917576 @default.
- W1994861432 cites W2007336029 @default.
- W1994861432 cites W2008498145 @default.
- W1994861432 cites W2008582329 @default.
- W1994861432 cites W2009194056 @default.
- W1994861432 cites W2010013468 @default.
- W1994861432 cites W2011474502 @default.
- W1994861432 cites W2012661561 @default.
- W1994861432 cites W2013472102 @default.
- W1994861432 cites W2014624348 @default.
- W1994861432 cites W2015616444 @default.
- W1994861432 cites W2016086822 @default.
- W1994861432 cites W2017060960 @default.
- W1994861432 cites W2017631156 @default.
- W1994861432 cites W2017728303 @default.
- W1994861432 cites W2019431066 @default.
- W1994861432 cites W2019995269 @default.
- W1994861432 cites W2020636054 @default.
- W1994861432 cites W2022635468 @default.
- W1994861432 cites W2025471241 @default.
- W1994861432 cites W2027950584 @default.
- W1994861432 cites W2029219396 @default.
- W1994861432 cites W2034269086 @default.
- W1994861432 cites W2035768602 @default.
- W1994861432 cites W2038596108 @default.
- W1994861432 cites W2039828110 @default.