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- W1994865782 endingPage "713" @default.
- W1994865782 startingPage "713" @default.
- W1994865782 abstract "Recent advances in the treatment of aplastic anemia (AA) made most of patients to expect to achieve a long-term survival. Allogeneic stem cell transplantation (SCT) from HLA-matched sibling donor (MSD-SCT) is a preferred first-line treatment option for younger patients with severe or very severe AA, whereas immunosuppressive treatment (IST) is an alternative option for others. Horse anti-thymocyte globuline (ATG) with cyclosporin A (CsA) had been a standard IST regimen with acceptable response rate. Recently, horse ATG had been not available and replaced with rabbit ATG in most countries. Subsequently, recent comparative studies showed that the outcomes of patients who received rabbit ATG/CsA were similar or inferior compared to those who received horse ATG/CsA. Therefore, further studies to improve the outcomes of IST, including additional eltrombopag, are necessary. On the other hand, the upper age limit of patients who are able to receive MSD-SCT as first-line treatment is a current issue because of favorable outcomes of MSD-SCT of older patients using fludarabine-based conditioning. In addition, further studies to improve the outcomes of patients who receive allogeneic SCT from alternative donors are needed. In this review, current issues and the newly emerging trends that may improve their outcomes in near futures will be discussed focusing the management of patients with AA." @default.
- W1994865782 created "2016-06-24" @default.
- W1994865782 creator A5050132118 @default.
- W1994865782 creator A5066664434 @default.
- W1994865782 creator A5085429434 @default.
- W1994865782 date "2014-01-01" @default.
- W1994865782 modified "2023-10-16" @default.
- W1994865782 title "Recent advances in treatment of aplastic anemia" @default.
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