FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994872783> ?p ?o ?g. }

• W1994872783 endingPage "1392" @default.
• W1994872783 startingPage "1381" @default.
• W1994872783 abstract "Saposin C is a lysosomal, membrane-binding protein that acts as an activator for the hydrolysis of glucosylceramide by the enzyme glucocerebrosidase. We used high-resolution NMR to determine the three-dimensional solution structure of saposin C in the presence of the detergent sodium dodecyl sulfate (SDS). This structure provides the first representation of membrane bound saposin C at the atomic level. In the presence of SDS, the protein adopts an open conformation with an exposed hydrophobic pocket. In contrast, the previously reported NMR structure of saposin C in the absence of SDS is compact and contains a hydrophobic core that is not exposed to the solvent. NMR data indicate that the SDS molecules interact with the hydrophobic pocket. The structure of saposin C in the presence of SDS is very similar to a monomer in the saposin B homodimer structure. Their comparison reveals possible similarity in the type of protein/lipid interaction as well as structural components differentiating their quaternary structures and functional specificity." @default.
• W1994872783 created "2016-06-24" @default.
• W1994872783 creator A5008234020 @default.
• W1994872783 creator A5025055935 @default.
• W1994872783 creator A5080735576 @default.
• W1994872783 date "2005-03-01" @default.
• W1994872783 modified "2023-09-23" @default.
• W1994872783 title "Solution Structure of Human Saposin C in a Detergent Environment" @default.
• W1994872783 cites W1504017858 @default.
• W1994872783 cites W1511618402 @default.
• W1994872783 cites W1550638522 @default.
• W1994872783 cites W1589295940 @default.
• W1994872783 cites W1678481706 @default.
• W1994872783 cites W1967682070 @default.
• W1994872783 cites W1968816228 @default.
• W1994872783 cites W1973621188 @default.
• W1994872783 cites W1975459052 @default.
• W1994872783 cites W1977920448 @default.
• W1994872783 cites W1980064805 @default.
• W1994872783 cites W1986785104 @default.
• W1994872783 cites W1996700062 @default.
• W1994872783 cites W1999406227 @default.
• W1994872783 cites W2002195659 @default.
• W1994872783 cites W2004854771 @default.
• W1994872783 cites W2006925909 @default.
• W1994872783 cites W2015226011 @default.
• W1994872783 cites W2018831991 @default.
• W1994872783 cites W2025717854 @default.
• W1994872783 cites W2030292488 @default.
• W1994872783 cites W2041844634 @default.
• W1994872783 cites W2053590485 @default.
• W1994872783 cites W2067100150 @default.
• W1994872783 cites W2071530096 @default.
• W1994872783 cites W2073486807 @default.
• W1994872783 cites W2087968879 @default.
• W1994872783 cites W2090565001 @default.
• W1994872783 cites W2091679142 @default.
• W1994872783 cites W2095532026 @default.
• W1994872783 cites W2105266773 @default.
• W1994872783 cites W2116966882 @default.
• W1994872783 cites W2121861656 @default.
• W1994872783 cites W2130688334 @default.
• W1994872783 cites W2141378441 @default.
• W1994872783 cites W2154101268 @default.
• W1994872783 cites W2169821755 @default.
• W1994872783 cites W2172105693 @default.
• W1994872783 cites W246748450 @default.
• W1994872783 cites W29253705 @default.
• W1994872783 cites W2951182529 @default.
• W1994872783 cites W4236258478 @default.
• W1994872783 cites W4242009576 @default.
• W1994872783 cites W4255420656 @default.
• W1994872783 doi "https://doi.org/10.1016/j.jmb.2004.12.045" @default.
• W1994872783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15713488" @default.
• W1994872783 hasPublicationYear "2005" @default.
• W1994872783 type Work @default.
• W1994872783 sameAs 1994872783 @default.
• W1994872783 citedByCount "59" @default.
• W1994872783 countsByYear W19948727832012 @default.
• W1994872783 countsByYear W19948727832014 @default.
• W1994872783 countsByYear W19948727832015 @default.
• W1994872783 countsByYear W19948727832016 @default.
• W1994872783 countsByYear W19948727832017 @default.
• W1994872783 countsByYear W19948727832018 @default.
• W1994872783 countsByYear W19948727832020 @default.
• W1994872783 countsByYear W19948727832021 @default.
• W1994872783 countsByYear W19948727832022 @default.
• W1994872783 crossrefType "journal-article" @default.
• W1994872783 hasAuthorship W1994872783A5008234020 @default.
• W1994872783 hasAuthorship W1994872783A5025055935 @default.
• W1994872783 hasAuthorship W1994872783A5080735576 @default.
• W1994872783 hasConcept C166940927 @default.
• W1994872783 hasConcept C178790620 @default.
• W1994872783 hasConcept C185592680 @default.
• W1994872783 hasConcept C2778913249 @default.
• W1994872783 hasConcept C47701112 @default.
• W1994872783 hasConcept C521977710 @default.
• W1994872783 hasConcept C55493867 @default.
• W1994872783 hasConcept C71240020 @default.
• W1994872783 hasConcept C8010536 @default.
• W1994872783 hasConceptScore W1994872783C166940927 @default.
• W1994872783 hasConceptScore W1994872783C178790620 @default.
• W1994872783 hasConceptScore W1994872783C185592680 @default.
• W1994872783 hasConceptScore W1994872783C2778913249 @default.
• W1994872783 hasConceptScore W1994872783C47701112 @default.
• W1994872783 hasConceptScore W1994872783C521977710 @default.
• W1994872783 hasConceptScore W1994872783C55493867 @default.
• W1994872783 hasConceptScore W1994872783C71240020 @default.
• W1994872783 hasConceptScore W1994872783C8010536 @default.
• W1994872783 hasIssue "5" @default.
• W1994872783 hasLocation W19948727831 @default.
• W1994872783 hasLocation W19948727832 @default.
• W1994872783 hasOpenAccess W1994872783 @default.
• W1994872783 hasPrimaryLocation W19948727831 @default.
• W1994872783 hasRelatedWork W1968494855 @default.
• W1994872783 hasRelatedWork W1977497482 @default.
• W1994872783 hasRelatedWork W1987922187 @default.
• W1994872783 hasRelatedWork W1997631102 @default.

• next