FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994882932> ?p ?o ?g. }

• W1994882932 endingPage "8030" @default.
• W1994882932 startingPage "8024" @default.
• W1994882932 abstract "The platelet and skeletal sarcoplasmic reticulum calcium-dependent adenosinetriphosphatases (Ca2+-ATPases) were functionally compared with respect to substrate activation by steady-state kinetic methods using the inhibitors quercetin and calmidazolium. Quercetin inhibited platelet and sarcoplasmic reticulum Ca2+-ATPase activities in a dose-dependent manner with IC50 values of 25 and 10 microM, respectively. Calmidazolium also inhibited platelet and sarcoplasmic reticulum Ca2+-ATPase activities, with half-maximal inhibition measured at 5 and 4 microM, respectively. Both inhibitors also affected the calcium transport activity of intact platelet microsomes at concentrations similar to those which reduced Ca2+-ATPase activity. These inhibitors were then used to examine substrate ligation by the platelet and sarcoplasmic reticulum calcium pump proteins. For both Ca2+-ATPase proteins, quercetin has an affinity for the E-Ca2 (fully ligated with respect to calcium at the exterior high-affinity calcium binding sites, unligated with respect to ATP) conformational state of the protein that is approximately 10-fold greater than for other conformational states in the hydrolytic cycle. Quercetin can thus be considered a competitive inhibitor of the calcium pump proteins with respect to ATP. In contrast to the effect of quercetin, calmidazolium interacts with the platelet and sarcoplasmic reticulum Ca2+-ATPases in an uncompetitive manner. The dissociation constants for this inhibitor for the different conformational states of the calcium pump proteins were similar, indicating that calmidazolium has equal affinity for all of the reaction intermediates probed. These observations indicate that the substrate ligation processes are similar for the two pump proteins. This supports the concept that the hydrolytic cycles of the two proteins are comparable." @default.
• W1994882932 created "2016-06-24" @default.
• W1994882932 creator A5019490847 @default.
• W1994882932 creator A5058914292 @default.
• W1994882932 creator A5085822063 @default.
• W1994882932 date "1987-12-01" @default.
• W1994882932 modified "2023-10-06" @default.
• W1994882932 title "An investigation of functional similarities between the sarcoplasmic reticulum and platelet calcium-dependent adenosinetriphosphatases with the inhibitors quercetin and calmidazolium" @default.
• W1994882932 cites W1516677878 @default.
• W1994882932 cites W1520273710 @default.
• W1994882932 cites W1523945129 @default.
• W1994882932 cites W1549745457 @default.
• W1994882932 cites W1576919957 @default.
• W1994882932 cites W1577394370 @default.
• W1994882932 cites W1595204022 @default.
• W1994882932 cites W1600684795 @default.
• W1994882932 cites W1646029847 @default.
• W1994882932 cites W1970024286 @default.
• W1994882932 cites W1978202577 @default.
• W1994882932 cites W1980648234 @default.
• W1994882932 cites W1983178353 @default.
• W1994882932 cites W1983585666 @default.
• W1994882932 cites W2022546465 @default.
• W1994882932 cites W2028151990 @default.
• W1994882932 cites W2038289301 @default.
• W1994882932 cites W2047120675 @default.
• W1994882932 cites W2060383918 @default.
• W1994882932 cites W2064775579 @default.
• W1994882932 cites W2065703248 @default.
• W1994882932 cites W2071165662 @default.
• W1994882932 cites W2080052515 @default.
• W1994882932 cites W2086220224 @default.
• W1994882932 cites W2094531044 @default.
• W1994882932 cites W2099743460 @default.
• W1994882932 cites W2102131116 @default.
• W1994882932 cites W2115429844 @default.
• W1994882932 cites W2117831772 @default.
• W1994882932 cites W2135393487 @default.
• W1994882932 cites W2152045900 @default.
• W1994882932 cites W2168824416 @default.
• W1994882932 cites W2415572347 @default.
• W1994882932 cites W309690782 @default.
• W1994882932 cites W92491876 @default.
• W1994882932 doi "https://doi.org/10.1021/bi00398a070" @default.
• W1994882932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2962642" @default.
• W1994882932 hasPublicationYear "1987" @default.
• W1994882932 type Work @default.
• W1994882932 sameAs 1994882932 @default.
• W1994882932 citedByCount "32" @default.
• W1994882932 countsByYear W19948829322013 @default.
• W1994882932 crossrefType "journal-article" @default.
• W1994882932 hasAuthorship W1994882932A5019490847 @default.
• W1994882932 hasAuthorship W1994882932A5058914292 @default.
• W1994882932 hasAuthorship W1994882932A5085822063 @default.
• W1994882932 hasBestOaLocation W19948829322 @default.
• W1994882932 hasConcept C101571972 @default.
• W1994882932 hasConcept C12554922 @default.
• W1994882932 hasConcept C158617107 @default.
• W1994882932 hasConcept C178790620 @default.
• W1994882932 hasConcept C181199279 @default.
• W1994882932 hasConcept C185592680 @default.
• W1994882932 hasConcept C23265538 @default.
• W1994882932 hasConcept C29688787 @default.
• W1994882932 hasConcept C519063684 @default.
• W1994882932 hasConcept C55493867 @default.
• W1994882932 hasConcept C86803240 @default.
• W1994882932 hasConceptScore W1994882932C101571972 @default.
• W1994882932 hasConceptScore W1994882932C12554922 @default.
• W1994882932 hasConceptScore W1994882932C158617107 @default.
• W1994882932 hasConceptScore W1994882932C178790620 @default.
• W1994882932 hasConceptScore W1994882932C181199279 @default.
• W1994882932 hasConceptScore W1994882932C185592680 @default.
• W1994882932 hasConceptScore W1994882932C23265538 @default.
• W1994882932 hasConceptScore W1994882932C29688787 @default.
• W1994882932 hasConceptScore W1994882932C519063684 @default.
• W1994882932 hasConceptScore W1994882932C55493867 @default.
• W1994882932 hasConceptScore W1994882932C86803240 @default.
• W1994882932 hasIssue "24" @default.
• W1994882932 hasLocation W19948829321 @default.
• W1994882932 hasLocation W19948829322 @default.
• W1994882932 hasLocation W19948829323 @default.
• W1994882932 hasOpenAccess W1994882932 @default.
• W1994882932 hasPrimaryLocation W19948829321 @default.
• W1994882932 hasRelatedWork W1997755857 @default.
• W1994882932 hasRelatedWork W2039570641 @default.
• W1994882932 hasRelatedWork W2043264869 @default.
• W1994882932 hasRelatedWork W2058095240 @default.
• W1994882932 hasRelatedWork W2062353778 @default.
• W1994882932 hasRelatedWork W2074121576 @default.
• W1994882932 hasRelatedWork W2081370158 @default.
• W1994882932 hasRelatedWork W2411173713 @default.
• W1994882932 hasRelatedWork W38146841 @default.
• W1994882932 hasRelatedWork W3120335657 @default.
• W1994882932 hasVolume "26" @default.
• W1994882932 isParatext "false" @default.
• W1994882932 isRetracted "false" @default.
• W1994882932 magId "1994882932" @default.
• W1994882932 workType "article" @default.