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- W1994886521 abstract "<h3>Summary</h3> Human centenarians and longevity mutants of model organisms show lower incidence rates of late-life morbidities than the average population. However, whether longevity is caused by a compression of the portion of life spent in a state of morbidity, <i>i</i>.<i>e</i>., “sickspan,” is highly debated even in isogenic <i>C. elegans</i>. Here, we developed a microfluidic device that employs acoustophoretic force fields to quantify the maximum muscle strength and dynamic power in aging <i>C. elegans</i>. Together with different biomarkers for healthspan, we found a stochastic onset of morbidity, starting with a decline in dynamic muscle power and structural integrity, culminating in frailty. Surprisingly, we did not observe a compression of sickspan in longevity mutants but instead observed a temporal scaling of healthspan. Given the conservation of these longevity interventions, this raises the question of whether the healthspan of mammalian longevity interventions is also temporally scaled." @default.
- W1994886521 created "2016-06-24" @default.
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- W1994886521 date "1965-12-01" @default.
- W1994886521 modified "2023-09-24" @default.
- W1994886521 title "Splenic Mechanisms in the Pathogenesis of Anaemia" @default.
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- W1994886521 doi "https://doi.org/10.1136/pgmj.41.482.748" @default.
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