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- W1994890913 abstract "Beta-thromboglobulin is a platelet protein which is released into the circulation upon lysis of platelets. Its plasma concentration is thought to be a sensitive indicator of platelet consumption. We tested the hypothesis that the plasma concentration of beta-thromboglobulin, a microprotein of 36.000 dalton, rises in renal failure, similar to beta-2-microglobulin. In 90 patients with varying degrees of renal failure, a highly significant correlation was found between beta-TG on the one hand and serum creatinine (r=0.78), CCR (r=0.73) and beta-2-microglobulin (r=0.76) on the other hand. The normal range (x ± SD) of beta-thromboglobulin was 33.9±9.7 ng/ ml. Values consistantly above 35 ng/ml were observed at serum creatinine 1.5 mg/dl. The findings support the conclusion that beta-thromboglobulin is a tubular protein the concentration of which rises in patients with renal failure. These findings invalidate the use of beta-thromboglobulin for detection of thrombosis in patients with impaired renal function unless the degree of renal failure is taken into account." @default.
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- W1994890913 date "1980-01-01" @default.
- W1994890913 modified "2023-09-26" @default.
- W1994890913 title "Beta-thromboglobulin is elevated in renal failure without thrombosis" @default.
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- W1994890913 doi "https://doi.org/10.1016/0049-3848(80)90294-7" @default.
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