FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994893199> ?p ?o ?g. }

• W1994893199 endingPage "6638" @default.
• W1994893199 startingPage "6632" @default.
• W1994893199 abstract "Abstract Purpose: The tumor suppressor p53 and DNA repair gene X-ray repair cross-complementing group 1 (XRCC1) are thought to play important roles on prostate cancer susceptibility and tumor development. We investigated the potential prognostic roles of p53 (codon 72) and XRCC1 (codons 194, 280, and 399) polymorphisms in clinical localized prostate cancer after radical prostatectomy. Experimental Design: A total of 126 clinical localized prostate cancer patients undergoing curative radical prostatectomy at the Kaohsiung Medical University Hospital and Kaohsiung Veterans General Hospital were included in this study. The p53 codon 72 and XRCC1 codons 194, 280 and 399 polymorphisms were determined by the PCR-RFLP method. Their prognostic significance on prostate-specific antigen (PSA) recurrence were assessed using the Kaplan-Meier analysis and Cox regression model. Results: The p53 codon 72 Arg/Arg genotype was associated with increased PSA recurrence risk compared with the Arg/Pro and Pro/Pro genotypes, although the difference did not reach significance (30.3% versus 20.4%, P = 0.247). Of these three XRCC1 polymorphisms, the codon 399 Arg/Gln + Gln/Gn genotypes were significantly associated with higher risk of PSA recurrence after radical prostatectomy compared with the Arg/Arg genotype (34.0% versus 15.1%, P = 0.013) and poorer PSA-free survival (log-rank test, P = 0.0056). After considering for other covariates in a Cox proportional hazard model, the XRCC1 Arg/Gln and Gln/Gln genotypes (hazard ratio, 4.73; 95% confidence interval, 1.61-13.92; P = 0.005) and high Gleason score (Gleason score, 8-10; hazard ratio, 5.58; 95% confidence interval, 1.58-19.71; P = 0.008) were still independent predictors of poor PSA-free survival after radical prostatectomy. The similar significant results were not found in XRCC1 codons 194 and 280. Conclusions: Our results suggest that the XRCC1 codon 399 polymorphism may be a prognostic factor for PSA recurrence after radical prostatectomy." @default.
• W1994893199 created "2016-06-24" @default.
• W1994893199 creator A5001159921 @default.
• W1994893199 creator A5030951075 @default.
• W1994893199 creator A5036186416 @default.
• W1994893199 creator A5038393119 @default.
• W1994893199 creator A5041679786 @default.
• W1994893199 creator A5045311583 @default.
• W1994893199 creator A5047341327 @default.
• W1994893199 creator A5050179357 @default.
• W1994893199 creator A5054033654 @default.
• W1994893199 creator A5067461518 @default.
• W1994893199 creator A5077154714 @default.
• W1994893199 creator A5090668350 @default.
• W1994893199 date "2007-11-15" @default.
• W1994893199 modified "2023-10-18" @default.
• W1994893199 title "Prognostic Significance of<i>p53</i>and<i>X-ray Repair Cross-complementing Group 1</i>Polymorphisms on Prostate-Specific Antigen Recurrence in Prostate Cancer Post–Radical Prostatectomy" @default.
• W1994893199 cites W1220153186 @default.
• W1994893199 cites W1964456103 @default.
• W1994893199 cites W1968111299 @default.
• W1994893199 cites W1970646140 @default.
• W1994893199 cites W1971913337 @default.
• W1994893199 cites W1971949046 @default.
• W1994893199 cites W1975323370 @default.
• W1994893199 cites W1976235816 @default.
• W1994893199 cites W1983585864 @default.
• W1994893199 cites W1996502576 @default.
• W1994893199 cites W2006115709 @default.
• W1994893199 cites W2008914008 @default.
• W1994893199 cites W2012071848 @default.
• W1994893199 cites W2022085298 @default.
• W1994893199 cites W2028340407 @default.
• W1994893199 cites W2042316019 @default.
• W1994893199 cites W2044261846 @default.
• W1994893199 cites W2054242539 @default.
• W1994893199 cites W2066583644 @default.
• W1994893199 cites W2071879495 @default.
• W1994893199 cites W2080902275 @default.
• W1994893199 cites W2100083322 @default.
• W1994893199 cites W2101943966 @default.
• W1994893199 cites W2102823703 @default.
• W1994893199 cites W2103438630 @default.
• W1994893199 cites W2104637985 @default.
• W1994893199 cites W2104870101 @default.
• W1994893199 cites W2105507193 @default.
• W1994893199 cites W2106277136 @default.
• W1994893199 cites W2120859422 @default.
• W1994893199 cites W2133232029 @default.
• W1994893199 cites W2134831636 @default.
• W1994893199 cites W2137773292 @default.
• W1994893199 cites W2139871731 @default.
• W1994893199 cites W2149017463 @default.
• W1994893199 cites W2149056940 @default.
• W1994893199 cites W2150097377 @default.
• W1994893199 cites W2165432409 @default.
• W1994893199 cites W2167968708 @default.
• W1994893199 cites W2404165232 @default.
• W1994893199 cites W3023689102 @default.
• W1994893199 cites W4234517679 @default.
• W1994893199 doi "https://doi.org/10.1158/1078-0432.ccr-07-1437" @default.
• W1994893199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18006764" @default.
• W1994893199 hasPublicationYear "2007" @default.
• W1994893199 type Work @default.
• W1994893199 sameAs 1994893199 @default.
• W1994893199 citedByCount "31" @default.
• W1994893199 countsByYear W19948931992012 @default.
• W1994893199 countsByYear W19948931992013 @default.
• W1994893199 countsByYear W19948931992014 @default.
• W1994893199 countsByYear W19948931992015 @default.
• W1994893199 countsByYear W19948931992016 @default.
• W1994893199 countsByYear W19948931992017 @default.
• W1994893199 countsByYear W19948931992023 @default.
• W1994893199 crossrefType "journal-article" @default.
• W1994893199 hasAuthorship W1994893199A5001159921 @default.
• W1994893199 hasAuthorship W1994893199A5030951075 @default.
• W1994893199 hasAuthorship W1994893199A5036186416 @default.
• W1994893199 hasAuthorship W1994893199A5038393119 @default.
• W1994893199 hasAuthorship W1994893199A5041679786 @default.
• W1994893199 hasAuthorship W1994893199A5045311583 @default.
• W1994893199 hasAuthorship W1994893199A5047341327 @default.
• W1994893199 hasAuthorship W1994893199A5050179357 @default.
• W1994893199 hasAuthorship W1994893199A5054033654 @default.
• W1994893199 hasAuthorship W1994893199A5067461518 @default.
• W1994893199 hasAuthorship W1994893199A5077154714 @default.
• W1994893199 hasAuthorship W1994893199A5090668350 @default.
• W1994893199 hasBestOaLocation W19948931991 @default.
• W1994893199 hasConcept C104317684 @default.
• W1994893199 hasConcept C121608353 @default.
• W1994893199 hasConcept C126322002 @default.
• W1994893199 hasConcept C126894567 @default.
• W1994893199 hasConcept C135763542 @default.
• W1994893199 hasConcept C143998085 @default.
• W1994893199 hasConcept C153209595 @default.
• W1994893199 hasConcept C207103383 @default.
• W1994893199 hasConcept C2776235491 @default.
• W1994893199 hasConcept C2776999993 @default.
• W1994893199 hasConcept C2777008409 @default.
• W1994893199 hasConcept C2779466945 @default.

• next