Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994900150> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1994900150 endingPage "229a" @default.
- W1994900150 startingPage "229a" @default.
- W1994900150 abstract "Islet amyloid polypetide (IAPP) is an intrinsically disordered protein co-expressed and secreted with insulin by pancreatic β-cells. IAPP is produced at increased rates in patients with pre-diabetes, leading to proteotoxicity and extracellular amyloid deposition, a hallmark of type-2 diabetes. We found high IAPP levels in blood and failing hearts from pre-diabetic and diabetic humans, showing that IAPP accumulates in the heart and may contribute to heart dysfunction. Here, we tested the hypothesis that accumulation of IAPP in the heart alters Ca handling in cardiac myocytes, accelerating the occurrence of heart failure. We measured Ca transients in rats transgenic for human IAPP (HIP rats) and in wild-type RIP rats that bear only the non-diabetogenic IAPP isoform. Ca transient amplitude was significantly larger in cardiac myocytes from pre-diabetic HIP rats vs. age-matched control rats. In contrast, pre-diabetic RIP rats showed unaltered Ca transients. We also found increased Ca transients in myocytes incubated with exogenous human IAPP but not with rodent IAPP. Increased cellular Ca load is involved in hypertrophic signaling and pathological remodeling of the heart. We measured the level of brain natriuretic peptide (BNP), a molecular marker of hypertrophy, in heart protein homogenates from HIP rats using western blots. BNP expression was already elevated (by 70±21%) in hearts from pre-diabetic rats vs. age-matched control littermates and further increased with diabetes development. These data show that cardiac Ca dysregulation and hypertrophy correlates with toxic deposition of IAPP in the heart. In conclusion, our data suggest that accumulation of IAPP oligomers contribute significantly to the pathogenesis of diabetic heart failure. IAPP represents an effective target for diagnostic purposes and therapeutic strategies." @default.
- W1994900150 created "2016-06-24" @default.
- W1994900150 creator A5020824899 @default.
- W1994900150 creator A5022651673 @default.
- W1994900150 creator A5031618666 @default.
- W1994900150 creator A5039503655 @default.
- W1994900150 creator A5048733831 @default.
- W1994900150 date "2011-02-01" @default.
- W1994900150 modified "2023-09-29" @default.
- W1994900150 title "Intrinsically Disordered Islet Amyloid Polypeptide Is a Pathogenic Link Between Type-2 diabetes and Heart Disease" @default.
- W1994900150 doi "https://doi.org/10.1016/j.bpj.2010.12.1467" @default.
- W1994900150 hasPublicationYear "2011" @default.
- W1994900150 type Work @default.
- W1994900150 sameAs 1994900150 @default.
- W1994900150 citedByCount "0" @default.
- W1994900150 crossrefType "journal-article" @default.
- W1994900150 hasAuthorship W1994900150A5020824899 @default.
- W1994900150 hasAuthorship W1994900150A5022651673 @default.
- W1994900150 hasAuthorship W1994900150A5031618666 @default.
- W1994900150 hasAuthorship W1994900150A5039503655 @default.
- W1994900150 hasAuthorship W1994900150A5048733831 @default.
- W1994900150 hasBestOaLocation W19949001501 @default.
- W1994900150 hasConcept C102230213 @default.
- W1994900150 hasConcept C104317684 @default.
- W1994900150 hasConcept C126322002 @default.
- W1994900150 hasConcept C134018914 @default.
- W1994900150 hasConcept C141035611 @default.
- W1994900150 hasConcept C142724271 @default.
- W1994900150 hasConcept C165220095 @default.
- W1994900150 hasConcept C167414201 @default.
- W1994900150 hasConcept C207200792 @default.
- W1994900150 hasConcept C2777180221 @default.
- W1994900150 hasConcept C2777633098 @default.
- W1994900150 hasConcept C2778198053 @default.
- W1994900150 hasConcept C2779306644 @default.
- W1994900150 hasConcept C2780705028 @default.
- W1994900150 hasConcept C55493867 @default.
- W1994900150 hasConcept C555293320 @default.
- W1994900150 hasConcept C71924100 @default.
- W1994900150 hasConcept C86803240 @default.
- W1994900150 hasConceptScore W1994900150C102230213 @default.
- W1994900150 hasConceptScore W1994900150C104317684 @default.
- W1994900150 hasConceptScore W1994900150C126322002 @default.
- W1994900150 hasConceptScore W1994900150C134018914 @default.
- W1994900150 hasConceptScore W1994900150C141035611 @default.
- W1994900150 hasConceptScore W1994900150C142724271 @default.
- W1994900150 hasConceptScore W1994900150C165220095 @default.
- W1994900150 hasConceptScore W1994900150C167414201 @default.
- W1994900150 hasConceptScore W1994900150C207200792 @default.
- W1994900150 hasConceptScore W1994900150C2777180221 @default.
- W1994900150 hasConceptScore W1994900150C2777633098 @default.
- W1994900150 hasConceptScore W1994900150C2778198053 @default.
- W1994900150 hasConceptScore W1994900150C2779306644 @default.
- W1994900150 hasConceptScore W1994900150C2780705028 @default.
- W1994900150 hasConceptScore W1994900150C55493867 @default.
- W1994900150 hasConceptScore W1994900150C555293320 @default.
- W1994900150 hasConceptScore W1994900150C71924100 @default.
- W1994900150 hasConceptScore W1994900150C86803240 @default.
- W1994900150 hasIssue "3" @default.
- W1994900150 hasLocation W19949001501 @default.
- W1994900150 hasOpenAccess W1994900150 @default.
- W1994900150 hasPrimaryLocation W19949001501 @default.
- W1994900150 hasRelatedWork W1972695818 @default.
- W1994900150 hasRelatedWork W1979023228 @default.
- W1994900150 hasRelatedWork W2007756574 @default.
- W1994900150 hasRelatedWork W2028240468 @default.
- W1994900150 hasRelatedWork W2065088608 @default.
- W1994900150 hasRelatedWork W2068677664 @default.
- W1994900150 hasRelatedWork W2098275043 @default.
- W1994900150 hasRelatedWork W2106098568 @default.
- W1994900150 hasRelatedWork W2121493897 @default.
- W1994900150 hasRelatedWork W2124249612 @default.
- W1994900150 hasRelatedWork W2155772596 @default.
- W1994900150 hasRelatedWork W2165973772 @default.
- W1994900150 hasRelatedWork W2270578170 @default.
- W1994900150 hasRelatedWork W2275422262 @default.
- W1994900150 hasRelatedWork W2769785166 @default.
- W1994900150 hasRelatedWork W287502931 @default.
- W1994900150 hasRelatedWork W2909545111 @default.
- W1994900150 hasRelatedWork W2970182255 @default.
- W1994900150 hasRelatedWork W2991834023 @default.
- W1994900150 hasRelatedWork W3203135632 @default.
- W1994900150 hasVolume "100" @default.
- W1994900150 isParatext "false" @default.
- W1994900150 isRetracted "false" @default.
- W1994900150 magId "1994900150" @default.
- W1994900150 workType "article" @default.