Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994902893> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1994902893 abstract "The zebrafish is a powerful model vertebrate amenable to high throughput in vivo genetic analyses. Examples include reverse genetic screens using morpholino knockdown, expression-based screening using enhancer trapping and forward genetic screening using transposon insertional mutagenesis. We have created a database to facilitate web-based distribution of data from such genetic studies. The MOrpholino DataBase is a MySQL relational database with an online, PHP interface. Multiple quality control levels allow differential access to data in raw and finished formats. MODBv1 includes sequence information relating to almost 800 morpholinos and their targets and phenotypic data regarding the dose effect of each morpholino (mortality, toxicity and defects). To improve the searchability of this database, we have incorporated a fixed-vocabulary defect ontology that allows for the organization of morpholino affects based on anatomical structure affected and defect produced. This also allows comparison between species utilizing Phenotypic Attribute Trait Ontology (PATO) designated terminology. MODB is also cross-linked with ZFIN, allowing full searches between the two databases. MODB offers users the ability to retrieve morpholino data by sequence of morpholino or target, name of target, anatomical structure affected and defect produced. MODB data can be used for functional genomic analysis of morpholino design to maximize efficacy and minimize toxicity. MODB also serves as a template for future sequence-based functional genetic screen databases, and it is currently being used as a model for the creation of a mutagenic insertional transposon database." @default.
- W1994902893 created "2016-06-24" @default.
- W1994902893 creator A5003815000 @default.
- W1994902893 creator A5028906755 @default.
- W1994902893 creator A5030598988 @default.
- W1994902893 creator A5030943120 @default.
- W1994902893 creator A5044571120 @default.
- W1994902893 creator A5051142815 @default.
- W1994902893 date "2008-01-07" @default.
- W1994902893 modified "2023-10-17" @default.
- W1994902893 title "A PATO-compliant zebrafish screening database (MODB): management of morpholino knockdown screen information" @default.
- W1994902893 cites W1495164740 @default.
- W1994902893 cites W1600642794 @default.
- W1994902893 cites W1840832740 @default.
- W1994902893 cites W1968606904 @default.
- W1994902893 cites W1984766519 @default.
- W1994902893 cites W1995127906 @default.
- W1994902893 cites W1998756807 @default.
- W1994902893 cites W2017256942 @default.
- W1994902893 cites W2055043387 @default.
- W1994902893 cites W2068621888 @default.
- W1994902893 cites W2077878665 @default.
- W1994902893 cites W2079363990 @default.
- W1994902893 cites W2084531609 @default.
- W1994902893 cites W2085064264 @default.
- W1994902893 cites W2102449913 @default.
- W1994902893 cites W2104990432 @default.
- W1994902893 cites W2115591173 @default.
- W1994902893 cites W2125349610 @default.
- W1994902893 cites W2132531056 @default.
- W1994902893 cites W2133045719 @default.
- W1994902893 cites W2133445706 @default.
- W1994902893 cites W2141744996 @default.
- W1994902893 cites W2155931743 @default.
- W1994902893 doi "https://doi.org/10.1186/1471-2105-9-7" @default.
- W1994902893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2221974" @default.
- W1994902893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18179718" @default.
- W1994902893 hasPublicationYear "2008" @default.
- W1994902893 type Work @default.
- W1994902893 sameAs 1994902893 @default.
- W1994902893 citedByCount "22" @default.
- W1994902893 countsByYear W19949028932012 @default.
- W1994902893 countsByYear W19949028932013 @default.
- W1994902893 countsByYear W19949028932014 @default.
- W1994902893 countsByYear W19949028932015 @default.
- W1994902893 countsByYear W19949028932016 @default.
- W1994902893 crossrefType "journal-article" @default.
- W1994902893 hasAuthorship W1994902893A5003815000 @default.
- W1994902893 hasAuthorship W1994902893A5028906755 @default.
- W1994902893 hasAuthorship W1994902893A5030598988 @default.
- W1994902893 hasAuthorship W1994902893A5030943120 @default.
- W1994902893 hasAuthorship W1994902893A5044571120 @default.
- W1994902893 hasAuthorship W1994902893A5051142815 @default.
- W1994902893 hasBestOaLocation W19949028931 @default.
- W1994902893 hasConcept C104317684 @default.
- W1994902893 hasConcept C136571751 @default.
- W1994902893 hasConcept C2776878037 @default.
- W1994902893 hasConcept C41008148 @default.
- W1994902893 hasConcept C54355233 @default.
- W1994902893 hasConcept C70721500 @default.
- W1994902893 hasConcept C77088390 @default.
- W1994902893 hasConcept C86803240 @default.
- W1994902893 hasConceptScore W1994902893C104317684 @default.
- W1994902893 hasConceptScore W1994902893C136571751 @default.
- W1994902893 hasConceptScore W1994902893C2776878037 @default.
- W1994902893 hasConceptScore W1994902893C41008148 @default.
- W1994902893 hasConceptScore W1994902893C54355233 @default.
- W1994902893 hasConceptScore W1994902893C70721500 @default.
- W1994902893 hasConceptScore W1994902893C77088390 @default.
- W1994902893 hasConceptScore W1994902893C86803240 @default.
- W1994902893 hasIssue "1" @default.
- W1994902893 hasLocation W19949028931 @default.
- W1994902893 hasLocation W19949028932 @default.
- W1994902893 hasLocation W19949028933 @default.
- W1994902893 hasLocation W19949028934 @default.
- W1994902893 hasOpenAccess W1994902893 @default.
- W1994902893 hasPrimaryLocation W19949028931 @default.
- W1994902893 hasRelatedWork W1015567707 @default.
- W1994902893 hasRelatedWork W1979534466 @default.
- W1994902893 hasRelatedWork W2216367787 @default.
- W1994902893 hasRelatedWork W2225511315 @default.
- W1994902893 hasRelatedWork W2809992820 @default.
- W1994902893 hasRelatedWork W2906185754 @default.
- W1994902893 hasRelatedWork W3081428433 @default.
- W1994902893 hasRelatedWork W3113189331 @default.
- W1994902893 hasRelatedWork W3143428212 @default.
- W1994902893 hasRelatedWork W3146363625 @default.
- W1994902893 hasVolume "9" @default.
- W1994902893 isParatext "false" @default.
- W1994902893 isRetracted "false" @default.
- W1994902893 magId "1994902893" @default.
- W1994902893 workType "article" @default.