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• W1994911745 abstract "cardiac remodeling refers to the changes in cardiac structure and function that develop in response to a variety of stimuli, including inflammatory and neurohormonal mediators and increases in wall stress. While some forms of remodeling are physiologically compensatory, such as the changes in cardiac structure that occur over time with strenuous exercise, others are maladaptive and their persistence causes a progressive worsening of cardiac function that leads to heart failure. A strong association between cardiac remodeling and mortality has been noted in heart failure patients (16). Pressure overload is an important cause of remodeling in human patients as it can occur from conditions such as hypertension or chamber outflow obstruction that are common in the population. Changes that occur in the heart in response to increases in pressure include cardiomyocyte hypertrophy and enhanced deposition of extracellular matrix proteins (i.e., fibrosis). Although some of these changes help compensate for increases in wall stress, over time they prove to be maladaptive as they result in abnormalities in both systolic and diastolic function (4). Although many of the pathways involved in the development of pressure overload remodeling have been identified, a full description of all of the “players” that contribute to the process is not yet available. Identification of novel pathways may help define novel strategies to prevent or reverse remodeling." @default.
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• W1994911745 date "2015-05-01" @default.
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• W1994911745 title "Cathepsins in heart disease–chewing on the heartache?" @default.
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• W1994911745 doi "https://doi.org/10.1152/ajpheart.00125.2015" @default.
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