Matches in SemOpenAlex for { <https://semopenalex.org/work/W1994920493> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W1994920493 endingPage "250" @default.
- W1994920493 startingPage "243" @default.
- W1994920493 abstract "An analysis has been made by matrix methods of the behaviour of a five-compartment system in which tracer is infused at a constant rate into the central compartment. This model has been used to interpret results obtained on serum, liver and muscle in rats receiving a constant intravenous infusion of [U- 14 C]lysine. The five compartments correspond to the free lysine pools of serum, liver and muscle and the protein pools of liver and muscle. When rate constants determined experimentally are inserted in the equations, it is shown that for the first few hours of infusion the specific activities in the five-pool model are virtually identical with those given by a three-pool model in which there are irreversible “leaks” of labelled lysine from the free lysine pools into the protein pools. It follows that in short experiments (less than ten hours) re-entry of labelled amino acid from the breakdown of labelled protein can be neglected without significant error. The specific activities of free lysine in serum, liver and muscle rapidly reach a quasi-plateau. The plateau specific activity is not the same in all three compartments, and is highest in serum. From the relative specific activities at plateau it is possible to calculate the extent to which intracellular lysine is derived from the breakdown of protein. The results showed that in liver 37% and in muscle 12% of lysine entering the intracellular pool was derived from protein catabolism. In the steady state these values also represent the extent to which, within each tissue, amino acids are reutilized for protein synthesis. If a steady state is assumed, and if the pool sizes, the plateau specific activities, and any one pair of rate constants are determined experimentally, all the rate constants of the system can be calculated." @default.
- W1994920493 created "2016-06-24" @default.
- W1994920493 creator A5061126107 @default.
- W1994920493 creator A5061578429 @default.
- W1994920493 date "1970-02-01" @default.
- W1994920493 modified "2023-09-23" @default.
- W1994920493 title "Analysis of a five-compartment system with continuous infusion and its application to the study of amino acid turnover" @default.
- W1994920493 cites W1973038387 @default.
- W1994920493 cites W2009096088 @default.
- W1994920493 cites W2032662782 @default.
- W1994920493 cites W2038525572 @default.
- W1994920493 cites W2053644850 @default.
- W1994920493 cites W2069645185 @default.
- W1994920493 cites W2071980718 @default.
- W1994920493 cites W2167424449 @default.
- W1994920493 cites W2339211839 @default.
- W1994920493 cites W4238524179 @default.
- W1994920493 cites W81000944 @default.
- W1994920493 doi "https://doi.org/10.1016/s0022-5193(70)80015-7" @default.
- W1994920493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5434345" @default.
- W1994920493 hasPublicationYear "1970" @default.
- W1994920493 type Work @default.
- W1994920493 sameAs 1994920493 @default.
- W1994920493 citedByCount "29" @default.
- W1994920493 countsByYear W19949204932017 @default.
- W1994920493 countsByYear W19949204932018 @default.
- W1994920493 crossrefType "journal-article" @default.
- W1994920493 hasAuthorship W1994920493A5061126107 @default.
- W1994920493 hasAuthorship W1994920493A5061578429 @default.
- W1994920493 hasConcept C111368507 @default.
- W1994920493 hasConcept C127313418 @default.
- W1994920493 hasConcept C185592680 @default.
- W1994920493 hasConcept C195580219 @default.
- W1994920493 hasConcept C203635412 @default.
- W1994920493 hasConcept C3675279 @default.
- W1994920493 hasConcept C515207424 @default.
- W1994920493 hasConcept C55493867 @default.
- W1994920493 hasConcept C86803240 @default.
- W1994920493 hasConceptScore W1994920493C111368507 @default.
- W1994920493 hasConceptScore W1994920493C127313418 @default.
- W1994920493 hasConceptScore W1994920493C185592680 @default.
- W1994920493 hasConceptScore W1994920493C195580219 @default.
- W1994920493 hasConceptScore W1994920493C203635412 @default.
- W1994920493 hasConceptScore W1994920493C3675279 @default.
- W1994920493 hasConceptScore W1994920493C515207424 @default.
- W1994920493 hasConceptScore W1994920493C55493867 @default.
- W1994920493 hasConceptScore W1994920493C86803240 @default.
- W1994920493 hasIssue "2" @default.
- W1994920493 hasLocation W19949204931 @default.
- W1994920493 hasLocation W19949204932 @default.
- W1994920493 hasOpenAccess W1994920493 @default.
- W1994920493 hasPrimaryLocation W19949204931 @default.
- W1994920493 hasRelatedWork W1971629342 @default.
- W1994920493 hasRelatedWork W1977237360 @default.
- W1994920493 hasRelatedWork W2063728635 @default.
- W1994920493 hasRelatedWork W2068888739 @default.
- W1994920493 hasRelatedWork W2113461079 @default.
- W1994920493 hasRelatedWork W2148960370 @default.
- W1994920493 hasRelatedWork W2409709568 @default.
- W1994920493 hasRelatedWork W2604165529 @default.
- W1994920493 hasRelatedWork W2952750033 @default.
- W1994920493 hasRelatedWork W2087394841 @default.
- W1994920493 hasVolume "26" @default.
- W1994920493 isParatext "false" @default.
- W1994920493 isRetracted "false" @default.
- W1994920493 magId "1994920493" @default.
- W1994920493 workType "article" @default.