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• W1994923672 abstract "Summary. Acute hepatitis C virus (HCV) infection evolves to chronicity in 50–84% cases. Treatment with interferon‐ α (IFN‐ α ) was repeatedly found to provide sustained cure rates higher than that in chronic HCV infection, but the optimal treatment strategy has not yet been defined. In a multicentre open‐label study, we investigated the therapeutic performance of a short course of pegylated (peg) IFN‐ α in patients with acute HCV hepatitis. Peg IFN‐ α 2b, 1.0–1.5 μ g/kg weekly, was administered for 12 weeks. Forty‐six patients were enrolled; 26 of them were intravenous drug users. Eleven patients had jaundice. Treatment was started within 1–90 days from the peak alanine aminotransferase. Treatment was well tolerated with a single dropout (2%). Thirty‐three of 46 patients (72%) had a sustained virological response (SVR) after a 6 months post‐treatment follow‐up, 8 (17%) relapsed after treatment and 4 were nonresponders (9%). A lower peak viraemia, receiving at least 1.2 μ g/kg of peg IFN‐ α , and a negative HCV‐RNA at week 4 and week 12 were predictors of SVR. Thus, in patients with early (week 4) viral response, a short course of peg IFN‐ α at a weekly dose >1.2 μ g/kg, may be a valuable option for the treatment of acute HCV hepatitis." @default.
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• W1994923672 date "2006-12-21" @default.
• W1994923672 modified "2023-10-16" @default.
• W1994923672 title "A short course of pegylated interferon-? in acute HCV hepatitis" @default.
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• W1994923672 doi "https://doi.org/10.1111/j.1365-2893.2006.00802.x" @default.
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